Trial Review

Registering a new trial?

To achieve prospective registration, we recommend submitting your trial for registration at the same time as ethics submission.

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been endorsed by the ANZCTR. Before participating in a study, talk to your health care provider and refer to this information for consumers
Trial details imported from ClinicalTrials.gov

For full trial details, please see the original record at https://clinicaltrials.gov/study/NCT02929329




Registration number
NCT02929329
Ethics application status
Date submitted
30/09/2016
Date registered
11/10/2016
Date last updated
5/11/2021

Titles & IDs
Public title
Registrational Study With Omecamtiv Mecarbil (AMG 423) to Treat Chronic Heart Failure With Reduced Ejection Fraction
Scientific title
A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Assess the Efficacy and Safety of Omecamtiv Mecarbil on Mortality and Morbidity in Subjects With Chronic Heart Failure With Reduced Ejection Fraction (GALACTIC-HF)
Secondary ID [1] 0 0
2016-002299-28
Secondary ID [2] 0 0
20110203
Universal Trial Number (UTN)
Trial acronym
GALACTIC-HF
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Heart Failure 0 0
Condition category
Condition code
Cardiovascular 0 0 0 0
Coronary heart disease
Cardiovascular 0 0 0 0
Other cardiovascular diseases

Intervention/exposure
Study type
Interventional
Description of intervention(s) / exposure
Treatment: Drugs - Omecamtiv Mecarbil
Treatment: Drugs - Placebo
Treatment: Drugs - Standard of Care

Experimental: Omecamtiv Mecarbil - Participants received oral omecamtiv mecarbil (OM) twice daily in addition to standard heart failure therapy. The starting dose of OM was 25 mg; At week 4, participants with week 2 OM predose plasma concentrations \< 200 ng/mL had their dose increased to 50 mg BID; participants with week 2 predose plasma concentrations = 200 and \< 300 ng/mL had their dose increased to 37.5 mg BID and participants with week 2 predose plasma concentrations = 300 ng/mL and \< 1000 ng/mL maintained a 25 mg BID dosing regimen.

Placebo comparator: Placebo - Participants received matching placebo tablets twice a day in addition to standard heart failure therapy.


Treatment: Drugs: Omecamtiv Mecarbil
Omecamtiv mecarbil tablets for oral administration

Treatment: Drugs: Placebo
Matching placebo tablets

Treatment: Drugs: Standard of Care
Participants were required to be optimally managed with standard of care therapies for chronic HF (eg, beta blockers, renin angiotensin aldosterone system inhibitors), consistent with regional clinical practice guidelines, unless contraindicated.
Intervention code [1] 0 0
Treatment: Drugs
Comparator / control treatment
Control group

Outcomes
Primary outcome [1] 0 0
Time to Cardiovascular Death or First Heart Failure Event
Timepoint [1] 0 0
From randomization to up to earliest of last confirmed survival status date or analysis cut-off date (07 August 2020); the overall median duration of follow-up was 21.8 months up to a maximum of 42 months.
Secondary outcome [1] 0 0
Time to Cardiovascular Death
Timepoint [1] 0 0
From randomization to up to earliest of last confirmed survival status date or analysis cut-off date (07 August 2020); the overall median duration of follow-up was 21.8 months up to a maximum of 42 months.
Secondary outcome [2] 0 0
Change From Baseline in Kansas City Cardiomyopathy Questionnaire Total Symptom Score (KCCQ TSS) at Week 24
Timepoint [2] 0 0
Baseline and Week 24
Secondary outcome [3] 0 0
Time to First Heart Failure Hospitalization
Timepoint [3] 0 0
From randomization to up to earliest of last confirmed survival status date or analysis cut-off date (07 August 2020); the overall median duration of follow-up was 21.8 months up to a maximum of 42 months.
Secondary outcome [4] 0 0
Time to All-cause Death
Timepoint [4] 0 0
From randomization up to earliest of last confirmed survival status date or analysis cut-off date (07 August 2020); the overall median duration of follow-up was 21.8 months up to a maximum of 42 months.

Eligibility
Key inclusion criteria
Key

* Subject has provided informed consent
* Male or female, = 18 to = 85 years
* History of chronic heart failure (HF), defined as requiring treatment for HF for a minimum of 30 days before randomization
* Left ventricle ejection fraction (LVEF) = 35%, per subjects most recent medical record, within 12 months prior to screening.
* New York Heart Association (NYHA) class II to IV at most recent screening assessment.
* Managed with HF standard of care (SoC) therapies consistent with regional clinical practice guidelines according to investigator judgment of subject's clinical status
* Current hospitalization with primary reason of HF OR one of the following events within 1 year of screening: hospitalization with primary reason of HF; urgent visit to emergency department (ED) with primary reason of HF.
* Elevated B-type natriuretic peptide (BNP) or n-terminal-prohormone brain natriuretic peptide (NT-proBNP)

Other Inclusion Criteria May apply

Key
Minimum age
18 Years
Maximum age
85 Years
Sex
Both males and females
Can healthy volunteers participate?
No
Key exclusion criteria
* Currently receiving treatment in another investigational device or drug study, or < 30 days since ending treatment on another investigational device or drug study(ies). Other investigational procedures while participating in this study are excluded.
* Malignancy within 5 years prior to randomization with the following exceptions: localized basal or squamous cell carcinoma of the skin, cervical intraepithelial neoplasia, stage 1 prostate carcinoma, breast ductal carcinoma in situ.
* Subject has known sensitivity to any of the products or components to be administered during testing

Other Exclusion Criteria May apply

Study design
Purpose of the study
Treatment
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Blinded (masking used)
Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s

The people analysing the results/data
Intervention assignment
Parallel
Other design features
Phase
Phase 3
Type of endpoint/s
Statistical methods / analysis

Recruitment
Recruitment status
Completed
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Anticipated
Actual
6/01/2017
Date of last participant enrolment
Anticipated
Actual
Date of last data collection
Anticipated
Actual
14/09/2020
Sample size
Target
Accrual to date
Final
8256
Recruitment in Australia
Recruitment state(s)
ACT,NSW,QLD,SA,VIC,WA
Recruitment hospital [1] 0 0
Research Site - Garran
Recruitment hospital [2] 0 0
Research Site - Concord
Recruitment hospital [3] 0 0
Research Site - Darlinghurst
Recruitment hospital [4] 0 0
Research Site - Liverpool
Recruitment hospital [5] 0 0
Research Site - New Lambton Heights
Recruitment hospital [6] 0 0
Research Site - Chermside
Recruitment hospital [7] 0 0
Research Site - Herston
Recruitment hospital [8] 0 0
Research Site - Woolloongabba
Recruitment hospital [9] 0 0
Research Site - Ashford
Recruitment hospital [10] 0 0
Research Site - Bedford Park
Recruitment hospital [11] 0 0
Research Site - Fullarton
Recruitment hospital [12] 0 0
Research Site - Woodville South
Recruitment hospital [13] 0 0
Research Site - Bundoora
Recruitment hospital [14] 0 0
Research Site - Frankston
Recruitment hospital [15] 0 0
Research Site - Geelong
Recruitment hospital [16] 0 0
Research Site - Richmond
Recruitment hospital [17] 0 0
Research Site - Murdoch
Recruitment postcode(s) [1] 0 0
2605 - Garran
Recruitment postcode(s) [2] 0 0
2139 - Concord
Recruitment postcode(s) [3] 0 0
2010 - Darlinghurst
Recruitment postcode(s) [4] 0 0
2170 - Liverpool
Recruitment postcode(s) [5] 0 0
2305 - New Lambton Heights
Recruitment postcode(s) [6] 0 0
4032 - Chermside
Recruitment postcode(s) [7] 0 0
4029 - Herston
Recruitment postcode(s) [8] 0 0
4102 - Woolloongabba
Recruitment postcode(s) [9] 0 0
5035 - Ashford
Recruitment postcode(s) [10] 0 0
5042 - Bedford Park
Recruitment postcode(s) [11] 0 0
5063 - Fullarton
Recruitment postcode(s) [12] 0 0
5011 - Woodville South
Recruitment postcode(s) [13] 0 0
3083 - Bundoora
Recruitment postcode(s) [14] 0 0
3199 - Frankston
Recruitment postcode(s) [15] 0 0
3220 - Geelong
Recruitment postcode(s) [16] 0 0
3121 - Richmond
Recruitment postcode(s) [17] 0 0
6150 - Murdoch
Recruitment outside Australia
Country [1] 0 0
United States of America
State/province [1] 0 0
Alabama
Country [2] 0 0
United States of America
State/province [2] 0 0
Arizona
Country [3] 0 0
United States of America
State/province [3] 0 0
Arkansas
Country [4] 0 0
United States of America
State/province [4] 0 0
California
Country [5] 0 0
United States of America
State/province [5] 0 0
Colorado
Country [6] 0 0
United States of America
State/province [6] 0 0
Connecticut
Country [7] 0 0
United States of America
State/province [7] 0 0
Delaware
Country [8] 0 0
United States of America
State/province [8] 0 0
District of Columbia
Country [9] 0 0
United States of America
State/province [9] 0 0
Florida
Country [10] 0 0
United States of America
State/province [10] 0 0
Georgia
Country [11] 0 0
United States of America
State/province [11] 0 0
Hawaii
Country [12] 0 0
United States of America
State/province [12] 0 0
Illinois
Country [13] 0 0
United States of America
State/province [13] 0 0
Indiana
Country [14] 0 0
United States of America
State/province [14] 0 0
Iowa
Country [15] 0 0
United States of America
State/province [15] 0 0
Kansas
Country [16] 0 0
United States of America
State/province [16] 0 0
Kentucky
Country [17] 0 0
United States of America
State/province [17] 0 0
Louisiana
Country [18] 0 0
United States of America
State/province [18] 0 0
Maine
Country [19] 0 0
United States of America
State/province [19] 0 0
Maryland
Country [20] 0 0
United States of America
State/province [20] 0 0
Massachusetts
Country [21] 0 0
United States of America
State/province [21] 0 0
Michigan
Country [22] 0 0
United States of America
State/province [22] 0 0
Minnesota
Country [23] 0 0
United States of America
State/province [23] 0 0
Mississippi
Country [24] 0 0
United States of America
State/province [24] 0 0
Missouri
Country [25] 0 0
United States of America
State/province [25] 0 0
Nebraska
Country [26] 0 0
United States of America
State/province [26] 0 0
Nevada
Country [27] 0 0
United States of America
State/province [27] 0 0
New Hampshire
Country [28] 0 0
United States of America
State/province [28] 0 0
New Jersey
Country [29] 0 0
United States of America
State/province [29] 0 0
New Mexico
Country [30] 0 0
United States of America
State/province [30] 0 0
New York
Country [31] 0 0
United States of America
State/province [31] 0 0
North Carolina
Country [32] 0 0
United States of America
State/province [32] 0 0
Ohio
Country [33] 0 0
United States of America
State/province [33] 0 0
Oklahoma
Country [34] 0 0
United States of America
State/province [34] 0 0
Pennsylvania
Country [35] 0 0
United States of America
State/province [35] 0 0
Rhode Island
Country [36] 0 0
United States of America
State/province [36] 0 0
South Carolina
Country [37] 0 0
United States of America
State/province [37] 0 0
South Dakota
Country [38] 0 0
United States of America
State/province [38] 0 0
Tennessee
Country [39] 0 0
United States of America
State/province [39] 0 0
Texas
Country [40] 0 0
United States of America
State/province [40] 0 0
Utah
Country [41] 0 0
United States of America
State/province [41] 0 0
Vermont
Country [42] 0 0
United States of America
State/province [42] 0 0
Virginia
Country [43] 0 0
United States of America
State/province [43] 0 0
Washington
Country [44] 0 0
United States of America
State/province [44] 0 0
West Virginia
Country [45] 0 0
United States of America
State/province [45] 0 0
Wisconsin
Country [46] 0 0
Argentina
State/province [46] 0 0
Buenos Aires
Country [47] 0 0
Argentina
State/province [47] 0 0
Córdoba
Country [48] 0 0
Argentina
State/province [48] 0 0
La Pampa
Country [49] 0 0
Argentina
State/province [49] 0 0
Santa Fe
Country [50] 0 0
Argentina
State/province [50] 0 0
Tucuman
Country [51] 0 0
Argentina
State/province [51] 0 0
Corrientes
Country [52] 0 0
Argentina
State/province [52] 0 0
Salta
Country [53] 0 0
Austria
State/province [53] 0 0
Feldkirch
Country [54] 0 0
Austria
State/province [54] 0 0
Graz
Country [55] 0 0
Austria
State/province [55] 0 0
Innsbruck
Country [56] 0 0
Austria
State/province [56] 0 0
Linz
Country [57] 0 0
Austria
State/province [57] 0 0
Sankt Poelten
Country [58] 0 0
Austria
State/province [58] 0 0
Villach
Country [59] 0 0
Austria
State/province [59] 0 0
Wien
Country [60] 0 0
Belgium
State/province [60] 0 0
Aalst
Country [61] 0 0
Belgium
State/province [61] 0 0
Genk
Country [62] 0 0
Belgium
State/province [62] 0 0
Gent
Country [63] 0 0
Belgium
State/province [63] 0 0
Leuven
Country [64] 0 0
Belgium
State/province [64] 0 0
Liège
Country [65] 0 0
Belgium
State/province [65] 0 0
Lodelinsart
Country [66] 0 0
Belgium
State/province [66] 0 0
Roeselare
Country [67] 0 0
Brazil
State/province [67] 0 0
Distrito Federal
Country [68] 0 0
Brazil
State/province [68] 0 0
Goiás
Country [69] 0 0
Brazil
State/province [69] 0 0
Minas Gerais
Country [70] 0 0
Brazil
State/province [70] 0 0
Paraná
Country [71] 0 0
Brazil
State/province [71] 0 0
Rio Grande Do Norte
Country [72] 0 0
Brazil
State/province [72] 0 0
Rio Grande Do Sul
Country [73] 0 0
Brazil
State/province [73] 0 0
Sergipe
Country [74] 0 0
Brazil
State/province [74] 0 0
São Paulo
Country [75] 0 0
Brazil
State/province [75] 0 0
Rio De Janeiro
Country [76] 0 0
Bulgaria
State/province [76] 0 0
Haskovo
Country [77] 0 0
Bulgaria
State/province [77] 0 0
Pleven
Country [78] 0 0
Bulgaria
State/province [78] 0 0
Sandanski
Country [79] 0 0
Bulgaria
State/province [79] 0 0
Sofia
Country [80] 0 0
Canada
State/province [80] 0 0
Alberta
Country [81] 0 0
Canada
State/province [81] 0 0
British Columbia
Country [82] 0 0
Canada
State/province [82] 0 0
Manitoba
Country [83] 0 0
Canada
State/province [83] 0 0
New Brunswick
Country [84] 0 0
Canada
State/province [84] 0 0
Newfoundland and Labrador
Country [85] 0 0
Canada
State/province [85] 0 0
Nova Scotia
Country [86] 0 0
Canada
State/province [86] 0 0
Ontario
Country [87] 0 0
Canada
State/province [87] 0 0
Quebec
Country [88] 0 0
Chile
State/province [88] 0 0
Cautín
Country [89] 0 0
Chile
State/province [89] 0 0
Concepción
Country [90] 0 0
Chile
State/province [90] 0 0
Santiago
Country [91] 0 0
Chile
State/province [91] 0 0
Valparaíso
Country [92] 0 0
Chile
State/province [92] 0 0
Osorno
Country [93] 0 0
China
State/province [93] 0 0
Beijing
Country [94] 0 0
China
State/province [94] 0 0
Guangdong
Country [95] 0 0
China
State/province [95] 0 0
Hainan
Country [96] 0 0
China
State/province [96] 0 0
Heilongjiang
Country [97] 0 0
China
State/province [97] 0 0
Henan
Country [98] 0 0
China
State/province [98] 0 0
Hunan
Country [99] 0 0
China
State/province [99] 0 0
Inner Mongolia
Country [100] 0 0
China
State/province [100] 0 0
Jiangsu
Country [101] 0 0
China
State/province [101] 0 0
Jilin
Country [102] 0 0
China
State/province [102] 0 0
Liaoning
Country [103] 0 0
China
State/province [103] 0 0
Shaanxi
Country [104] 0 0
China
State/province [104] 0 0
Shandong
Country [105] 0 0
China
State/province [105] 0 0
Shanxi
Country [106] 0 0
China
State/province [106] 0 0
Tianjin
Country [107] 0 0
China
State/province [107] 0 0
Xinjiang
Country [108] 0 0
China
State/province [108] 0 0
Zhejiang
Country [109] 0 0
China
State/province [109] 0 0
Shanghai
Country [110] 0 0
Colombia
State/province [110] 0 0
Antioquia
Country [111] 0 0
Colombia
State/province [111] 0 0
Atlántico
Country [112] 0 0
Colombia
State/province [112] 0 0
Bolívar
Country [113] 0 0
Colombia
State/province [113] 0 0
Caldas
Country [114] 0 0
Colombia
State/province [114] 0 0
Quindío
Country [115] 0 0
Colombia
State/province [115] 0 0
Santander
Country [116] 0 0
Colombia
State/province [116] 0 0
Valle Del Cauca
Country [117] 0 0
Colombia
State/province [117] 0 0
Bogota D.C.
Country [118] 0 0
Czechia
State/province [118] 0 0
Beroun
Country [119] 0 0
Czechia
State/province [119] 0 0
Brandys nad Labem
Country [120] 0 0
Czechia
State/province [120] 0 0
Brno
Country [121] 0 0
Czechia
State/province [121] 0 0
Frydek Mistek
Country [122] 0 0
Czechia
State/province [122] 0 0
Havlickuv Brod
Country [123] 0 0
Czechia
State/province [123] 0 0
Hradec Kralove
Country [124] 0 0
Czechia
State/province [124] 0 0
Jihlava
Country [125] 0 0
Czechia
State/province [125] 0 0
Karlovy Vary
Country [126] 0 0
Czechia
State/province [126] 0 0
Kladno
Country [127] 0 0
Czechia
State/province [127] 0 0
Klatovy IV
Country [128] 0 0
Czechia
State/province [128] 0 0
Kolin III
Country [129] 0 0
Czechia
State/province [129] 0 0
Liberec
Country [130] 0 0
Czechia
State/province [130] 0 0
Louny
Country [131] 0 0
Czechia
State/province [131] 0 0
Marianske Lazne
Country [132] 0 0
Czechia
State/province [132] 0 0
Mohelnice
Country [133] 0 0
Czechia
State/province [133] 0 0
Opava
Country [134] 0 0
Czechia
State/province [134] 0 0
Ostrava
Country [135] 0 0
Czechia
State/province [135] 0 0
Policka
Country [136] 0 0
Czechia
State/province [136] 0 0
Praha 10
Country [137] 0 0
Czechia
State/province [137] 0 0
Praha 1
Country [138] 0 0
Czechia
State/province [138] 0 0
Praha 2
Country [139] 0 0
Czechia
State/province [139] 0 0
Praha 5 - Smichov
Country [140] 0 0
Czechia
State/province [140] 0 0
Pribram VIII
Country [141] 0 0
Czechia
State/province [141] 0 0
Svitavy
Country [142] 0 0
Czechia
State/province [142] 0 0
Teplice
Country [143] 0 0
Czechia
State/province [143] 0 0
Uherske Hradiste
Country [144] 0 0
Czechia
State/province [144] 0 0
Zlin
Country [145] 0 0
Czechia
State/province [145] 0 0
Znojmo
Country [146] 0 0
Denmark
State/province [146] 0 0
Aalborg
Country [147] 0 0
Denmark
State/province [147] 0 0
Aarhus N
Country [148] 0 0
Denmark
State/province [148] 0 0
Esbjerg
Country [149] 0 0
Denmark
State/province [149] 0 0
Glostrup
Country [150] 0 0
Denmark
State/province [150] 0 0
Hellerup
Country [151] 0 0
Denmark
State/province [151] 0 0
Hillerod
Country [152] 0 0
Denmark
State/province [152] 0 0
Køge
Country [153] 0 0
Denmark
State/province [153] 0 0
Odense
Country [154] 0 0
Denmark
State/province [154] 0 0
Svendborg
Country [155] 0 0
France
State/province [155] 0 0
Beziers cedex
Country [156] 0 0
France
State/province [156] 0 0
Caen Cedex 9
Country [157] 0 0
France
State/province [157] 0 0
Chambray les Tours
Country [158] 0 0
France
State/province [158] 0 0
Corbeil Essonnes
Country [159] 0 0
France
State/province [159] 0 0
Créteil Cedex
Country [160] 0 0
France
State/province [160] 0 0
Dijon
Country [161] 0 0
France
State/province [161] 0 0
Grenoble Cedex 9
Country [162] 0 0
France
State/province [162] 0 0
Le Chesnay
Country [163] 0 0
France
State/province [163] 0 0
Lille Cedex
Country [164] 0 0
France
State/province [164] 0 0
Lille
Country [165] 0 0
France
State/province [165] 0 0
Limoges Cedex
Country [166] 0 0
France
State/province [166] 0 0
Lyon Cedex 03
Country [167] 0 0
France
State/province [167] 0 0
Montauban
Country [168] 0 0
France
State/province [168] 0 0
Montpellier cedex 05
Country [169] 0 0
France
State/province [169] 0 0
Nantes Cedex 1
Country [170] 0 0
France
State/province [170] 0 0
Nantes Cedex 2
Country [171] 0 0
France
State/province [171] 0 0
Nimes cedex 9
Country [172] 0 0
France
State/province [172] 0 0
Paris Cedex 13
Country [173] 0 0
France
State/province [173] 0 0
Paris
Country [174] 0 0
France
State/province [174] 0 0
Pessac Cedex
Country [175] 0 0
France
State/province [175] 0 0
Poitiers
Country [176] 0 0
France
State/province [176] 0 0
Rennes Cedex 9
Country [177] 0 0
France
State/province [177] 0 0
Saint Denis
Country [178] 0 0
France
State/province [178] 0 0
Toulon Cedex
Country [179] 0 0
France
State/province [179] 0 0
Toulouse Cedex 9
Country [180] 0 0
France
State/province [180] 0 0
Tourcoing cedex
Country [181] 0 0
France
State/province [181] 0 0
Valenciennes
Country [182] 0 0
Germany
State/province [182] 0 0
Bad Neuheim
Country [183] 0 0
Germany
State/province [183] 0 0
Berlin
Country [184] 0 0
Germany
State/province [184] 0 0
Dortmund
Country [185] 0 0
Germany
State/province [185] 0 0
Düsseldorf
Country [186] 0 0
Germany
State/province [186] 0 0
Erfurt
Country [187] 0 0
Germany
State/province [187] 0 0
Essen
Country [188] 0 0
Germany
State/province [188] 0 0
Frankfurt am Main
Country [189] 0 0
Germany
State/province [189] 0 0
Freiburg
Country [190] 0 0
Germany
State/province [190] 0 0
Greifswald
Country [191] 0 0
Germany
State/province [191] 0 0
Göttingen
Country [192] 0 0
Germany
State/province [192] 0 0
Haßloch
Country [193] 0 0
Germany
State/province [193] 0 0
Heidelberg
Country [194] 0 0
Germany
State/province [194] 0 0
Homburg
Country [195] 0 0
Germany
State/province [195] 0 0
Köln
Country [196] 0 0
Germany
State/province [196] 0 0
Langen
Country [197] 0 0
Germany
State/province [197] 0 0
Leipzig
Country [198] 0 0
Germany
State/province [198] 0 0
Ludwigshafen
Country [199] 0 0
Germany
State/province [199] 0 0
Mainz
Country [200] 0 0
Germany
State/province [200] 0 0
Markleeberg
Country [201] 0 0
Germany
State/province [201] 0 0
Witten
Country [202] 0 0
Germany
State/province [202] 0 0
Würzburg
Country [203] 0 0
Greece
State/province [203] 0 0
Alexandroupoli
Country [204] 0 0
Greece
State/province [204] 0 0
Athens
Country [205] 0 0
Greece
State/province [205] 0 0
Chaidari, Athens
Country [206] 0 0
Greece
State/province [206] 0 0
Chalkida
Country [207] 0 0
Greece
State/province [207] 0 0
Heraklion
Country [208] 0 0
Greece
State/province [208] 0 0
Ioannina
Country [209] 0 0
Greece
State/province [209] 0 0
Larissa
Country [210] 0 0
Greece
State/province [210] 0 0
Thessaloniki
Country [211] 0 0
Hungary
State/province [211] 0 0
Balatonfured
Country [212] 0 0
Hungary
State/province [212] 0 0
Bekescsaba
Country [213] 0 0
Hungary
State/province [213] 0 0
Berettyoujfalu
Country [214] 0 0
Hungary
State/province [214] 0 0
Budapest
Country [215] 0 0
Hungary
State/province [215] 0 0
Cegled
Country [216] 0 0
Hungary
State/province [216] 0 0
Dunaujvaros
Country [217] 0 0
Hungary
State/province [217] 0 0
Gyongyos
Country [218] 0 0
Hungary
State/province [218] 0 0
Gyula
Country [219] 0 0
Hungary
State/province [219] 0 0
Kaposvar
Country [220] 0 0
Hungary
State/province [220] 0 0
Komarom
Country [221] 0 0
Hungary
State/province [221] 0 0
Nyiregyhaza
Country [222] 0 0
Hungary
State/province [222] 0 0
Pecs
Country [223] 0 0
Hungary
State/province [223] 0 0
Sopron
Country [224] 0 0
Hungary
State/province [224] 0 0
Szeged
Country [225] 0 0
Hungary
State/province [225] 0 0
Szekszard
Country [226] 0 0
Hungary
State/province [226] 0 0
Szentes
Country [227] 0 0
Hungary
State/province [227] 0 0
Szolnok
Country [228] 0 0
Hungary
State/province [228] 0 0
Zalaegerszeg
Country [229] 0 0
Italy
State/province [229] 0 0
Ariccia
Country [230] 0 0
Italy
State/province [230] 0 0
Arzignano
Country [231] 0 0
Italy
State/province [231] 0 0
Bergamo
Country [232] 0 0
Italy
State/province [232] 0 0
Bologna
Country [233] 0 0
Italy
State/province [233] 0 0
Brescia
Country [234] 0 0
Italy
State/province [234] 0 0
Cagliari
Country [235] 0 0
Italy
State/province [235] 0 0
Catania
Country [236] 0 0
Italy
State/province [236] 0 0
Catanzaro
Country [237] 0 0
Italy
State/province [237] 0 0
Cona FE
Country [238] 0 0
Italy
State/province [238] 0 0
Cuneo
Country [239] 0 0
Italy
State/province [239] 0 0
Foggia
Country [240] 0 0
Italy
State/province [240] 0 0
Milano
Country [241] 0 0
Italy
State/province [241] 0 0
Monza (MB)
Country [242] 0 0
Italy
State/province [242] 0 0
Monza
Country [243] 0 0
Italy
State/province [243] 0 0
Napoli
Country [244] 0 0
Italy
State/province [244] 0 0
Palermo
Country [245] 0 0
Italy
State/province [245] 0 0
Pavia
Country [246] 0 0
Italy
State/province [246] 0 0
Perugia
Country [247] 0 0
Italy
State/province [247] 0 0
Piacenza
Country [248] 0 0
Italy
State/province [248] 0 0
Rimini
Country [249] 0 0
Italy
State/province [249] 0 0
Roma
Country [250] 0 0
Italy
State/province [250] 0 0
Rozzano MI
Country [251] 0 0
Italy
State/province [251] 0 0
Seriate
Country [252] 0 0
Italy
State/province [252] 0 0
Siena
Country [253] 0 0
Italy
State/province [253] 0 0
Torrette Di Ancona
Country [254] 0 0
Italy
State/province [254] 0 0
Trieste
Country [255] 0 0
Italy
State/province [255] 0 0
Vimercate MB
Country [256] 0 0
Japan
State/province [256] 0 0
Aichi
Country [257] 0 0
Japan
State/province [257] 0 0
Chiba
Country [258] 0 0
Japan
State/province [258] 0 0
Ehime
Country [259] 0 0
Japan
State/province [259] 0 0
Fukuoka
Country [260] 0 0
Japan
State/province [260] 0 0
Fukushima
Country [261] 0 0
Japan
State/province [261] 0 0
Gifu
Country [262] 0 0
Japan
State/province [262] 0 0
Gunma
Country [263] 0 0
Japan
State/province [263] 0 0
Hiroshima
Country [264] 0 0
Japan
State/province [264] 0 0
Hokkaido
Country [265] 0 0
Japan
State/province [265] 0 0
Hyogo
Country [266] 0 0
Japan
State/province [266] 0 0
Ibaraki
Country [267] 0 0
Japan
State/province [267] 0 0
Ishikawa
Country [268] 0 0
Japan
State/province [268] 0 0
Iwate
Country [269] 0 0
Japan
State/province [269] 0 0
Kagawa
Country [270] 0 0
Japan
State/province [270] 0 0
Kanagawa
Country [271] 0 0
Japan
State/province [271] 0 0
Kochi
Country [272] 0 0
Japan
State/province [272] 0 0
Kumamoto
Country [273] 0 0
Japan
State/province [273] 0 0
Miyagi
Country [274] 0 0
Japan
State/province [274] 0 0
Nagano
Country [275] 0 0
Japan
State/province [275] 0 0
Nara
Country [276] 0 0
Japan
State/province [276] 0 0
Oita
Country [277] 0 0
Japan
State/province [277] 0 0
Okayama
Country [278] 0 0
Japan
State/province [278] 0 0
Okinawa
Country [279] 0 0
Japan
State/province [279] 0 0
Osaka
Country [280] 0 0
Japan
State/province [280] 0 0
Saga
Country [281] 0 0
Japan
State/province [281] 0 0
Saitama
Country [282] 0 0
Japan
State/province [282] 0 0
Shiga
Country [283] 0 0
Japan
State/province [283] 0 0
Shizuoka
Country [284] 0 0
Japan
State/province [284] 0 0
Tokyo
Country [285] 0 0
Japan
State/province [285] 0 0
Toyama
Country [286] 0 0
Lithuania
State/province [286] 0 0
Kaunas
Country [287] 0 0
Lithuania
State/province [287] 0 0
Klaipeda
Country [288] 0 0
Lithuania
State/province [288] 0 0
Vilnius
Country [289] 0 0
Mexico
State/province [289] 0 0
Coahuila
Country [290] 0 0
Mexico
State/province [290] 0 0
Distrito Federal
Country [291] 0 0
Mexico
State/province [291] 0 0
Hidalgo
Country [292] 0 0
Mexico
State/province [292] 0 0
Jalisco
Country [293] 0 0
Mexico
State/province [293] 0 0
Nuevo León
Country [294] 0 0
Mexico
State/province [294] 0 0
Querétaro
Country [295] 0 0
Mexico
State/province [295] 0 0
San Luis Potosí
Country [296] 0 0
Mexico
State/province [296] 0 0
Sinaloa
Country [297] 0 0
Mexico
State/province [297] 0 0
Veracruz
Country [298] 0 0
Mexico
State/province [298] 0 0
Aguascalientes
Country [299] 0 0
Netherlands
State/province [299] 0 0
's Hertogenbosch
Country [300] 0 0
Netherlands
State/province [300] 0 0
Almelo
Country [301] 0 0
Netherlands
State/province [301] 0 0
Arnhem
Country [302] 0 0
Netherlands
State/province [302] 0 0
Breda
Country [303] 0 0
Netherlands
State/province [303] 0 0
Capelle Aan De IJssel
Country [304] 0 0
Netherlands
State/province [304] 0 0
Den Helder
Country [305] 0 0
Netherlands
State/province [305] 0 0
Deventer
Country [306] 0 0
Netherlands
State/province [306] 0 0
Doetinchem
Country [307] 0 0
Netherlands
State/province [307] 0 0
Emmen
Country [308] 0 0
Netherlands
State/province [308] 0 0
Goes
Country [309] 0 0
Netherlands
State/province [309] 0 0
Groningen
Country [310] 0 0
Netherlands
State/province [310] 0 0
Leiderdorp
Country [311] 0 0
Netherlands
State/province [311] 0 0
Nijmegen
Country [312] 0 0
Netherlands
State/province [312] 0 0
Tiel
Country [313] 0 0
Netherlands
State/province [313] 0 0
Tilburg
Country [314] 0 0
Netherlands
State/province [314] 0 0
Uden
Country [315] 0 0
Netherlands
State/province [315] 0 0
Zwolle
Country [316] 0 0
New Zealand
State/province [316] 0 0
Christchurch
Country [317] 0 0
New Zealand
State/province [317] 0 0
Papatoetoe, Auckland
Country [318] 0 0
New Zealand
State/province [318] 0 0
Takapuna, Auckland
Country [319] 0 0
Poland
State/province [319] 0 0
Bialystok
Country [320] 0 0
Poland
State/province [320] 0 0
Bytom
Country [321] 0 0
Poland
State/province [321] 0 0
Gdansk
Country [322] 0 0
Poland
State/province [322] 0 0
Gdynia
Country [323] 0 0
Poland
State/province [323] 0 0
Gizycko
Country [324] 0 0
Poland
State/province [324] 0 0
Kazimierza Wielka
Country [325] 0 0
Poland
State/province [325] 0 0
Kielce
Country [326] 0 0
Poland
State/province [326] 0 0
Klodzko
Country [327] 0 0
Poland
State/province [327] 0 0
Krakow
Country [328] 0 0
Poland
State/province [328] 0 0
Lodz
Country [329] 0 0
Poland
State/province [329] 0 0
Lublin
Country [330] 0 0
Poland
State/province [330] 0 0
Miechow
Country [331] 0 0
Poland
State/province [331] 0 0
Olawa
Country [332] 0 0
Poland
State/province [332] 0 0
Piotrkow Trybunalski
Country [333] 0 0
Poland
State/province [333] 0 0
Poznan
Country [334] 0 0
Poland
State/province [334] 0 0
Ruda Slaska
Country [335] 0 0
Poland
State/province [335] 0 0
Skierniewice
Country [336] 0 0
Poland
State/province [336] 0 0
Stalowa Wola
Country [337] 0 0
Poland
State/province [337] 0 0
Swidnik
Country [338] 0 0
Poland
State/province [338] 0 0
Tarnow
Country [339] 0 0
Poland
State/province [339] 0 0
Torun
Country [340] 0 0
Poland
State/province [340] 0 0
Warszawa
Country [341] 0 0
Poland
State/province [341] 0 0
Wloclawek
Country [342] 0 0
Poland
State/province [342] 0 0
Wroclaw
Country [343] 0 0
Poland
State/province [343] 0 0
Zabrze
Country [344] 0 0
Portugal
State/province [344] 0 0
Aveiro
Country [345] 0 0
Portugal
State/province [345] 0 0
Coimbra
Country [346] 0 0
Portugal
State/province [346] 0 0
Covilha
Country [347] 0 0
Portugal
State/province [347] 0 0
Guimaraes
Country [348] 0 0
Portugal
State/province [348] 0 0
Lisboa
Country [349] 0 0
Portugal
State/province [349] 0 0
Setubal
Country [350] 0 0
Puerto Rico
State/province [350] 0 0
San Juan
Country [351] 0 0
Romania
State/province [351] 0 0
Bucarest
Country [352] 0 0
Romania
State/province [352] 0 0
Bucharest
Country [353] 0 0
Romania
State/province [353] 0 0
Bucuresti
Country [354] 0 0
Romania
State/province [354] 0 0
Cluj-Napoca
Country [355] 0 0
Romania
State/province [355] 0 0
Craiova
Country [356] 0 0
Romania
State/province [356] 0 0
Iasi
Country [357] 0 0
Romania
State/province [357] 0 0
Oradea
Country [358] 0 0
Romania
State/province [358] 0 0
Pitesti
Country [359] 0 0
Romania
State/province [359] 0 0
Targoviste
Country [360] 0 0
Romania
State/province [360] 0 0
Targu Mures
Country [361] 0 0
Romania
State/province [361] 0 0
Timisoara
Country [362] 0 0
Russian Federation
State/province [362] 0 0
Arkhangelsk
Country [363] 0 0
Russian Federation
State/province [363] 0 0
Barnaul
Country [364] 0 0
Russian Federation
State/province [364] 0 0
Ekaterinburg
Country [365] 0 0
Russian Federation
State/province [365] 0 0
Ivanovo
Country [366] 0 0
Russian Federation
State/province [366] 0 0
Izhevsk
Country [367] 0 0
Russian Federation
State/province [367] 0 0
Kemerovo
Country [368] 0 0
Russian Federation
State/province [368] 0 0
Kirov
Country [369] 0 0
Russian Federation
State/province [369] 0 0
Korolev
Country [370] 0 0
Russian Federation
State/province [370] 0 0
Krasnodar
Country [371] 0 0
Russian Federation
State/province [371] 0 0
Lomonosov
Country [372] 0 0
Russian Federation
State/province [372] 0 0
Moscow
Country [373] 0 0
Russian Federation
State/province [373] 0 0
Nizhniy Novgorod
Country [374] 0 0
Russian Federation
State/province [374] 0 0
Nizhny Novgorod
Country [375] 0 0
Russian Federation
State/province [375] 0 0
Novosibirsk
Country [376] 0 0
Russian Federation
State/province [376] 0 0
Omsk
Country [377] 0 0
Russian Federation
State/province [377] 0 0
Saint Petersburg
Country [378] 0 0
Russian Federation
State/province [378] 0 0
Saint-Petersburg
Country [379] 0 0
Russian Federation
State/province [379] 0 0
Saratov
Country [380] 0 0
Russian Federation
State/province [380] 0 0
St. Petersburg
Country [381] 0 0
Russian Federation
State/province [381] 0 0
Tomsk
Country [382] 0 0
Russian Federation
State/province [382] 0 0
Village Novoseltsy
Country [383] 0 0
Russian Federation
State/province [383] 0 0
Vladimir
Country [384] 0 0
Russian Federation
State/province [384] 0 0
Yaroslavl
Country [385] 0 0
Slovakia
State/province [385] 0 0
Banska Bystrica
Country [386] 0 0
Slovakia
State/province [386] 0 0
Bardejov
Country [387] 0 0
Slovakia
State/province [387] 0 0
Bratislava
Country [388] 0 0
Slovakia
State/province [388] 0 0
Brezno
Country [389] 0 0
Slovakia
State/province [389] 0 0
Kosice
Country [390] 0 0
Slovakia
State/province [390] 0 0
Levice
Country [391] 0 0
Slovakia
State/province [391] 0 0
Nitra
Country [392] 0 0
Slovakia
State/province [392] 0 0
Presov
Country [393] 0 0
Slovakia
State/province [393] 0 0
Rimavska Sobota
Country [394] 0 0
Slovakia
State/province [394] 0 0
Snina
Country [395] 0 0
Slovakia
State/province [395] 0 0
Svidnik
Country [396] 0 0
Slovakia
State/province [396] 0 0
Trnava
Country [397] 0 0
South Africa
State/province [397] 0 0
Free State
Country [398] 0 0
South Africa
State/province [398] 0 0
Gauteng
Country [399] 0 0
South Africa
State/province [399] 0 0
KwaZulu-Natal
Country [400] 0 0
South Africa
State/province [400] 0 0
Western Cape
Country [401] 0 0
Spain
State/province [401] 0 0
Andalucía
Country [402] 0 0
Spain
State/province [402] 0 0
Aragón
Country [403] 0 0
Spain
State/province [403] 0 0
Asturias
Country [404] 0 0
Spain
State/province [404] 0 0
Canarias
Country [405] 0 0
Spain
State/province [405] 0 0
Cantabria
Country [406] 0 0
Spain
State/province [406] 0 0
Castilla León
Country [407] 0 0
Spain
State/province [407] 0 0
Cataluña
Country [408] 0 0
Spain
State/province [408] 0 0
Comunidad Valenciana
Country [409] 0 0
Spain
State/province [409] 0 0
Galicia
Country [410] 0 0
Spain
State/province [410] 0 0
Madrid
Country [411] 0 0
Spain
State/province [411] 0 0
Murcia
Country [412] 0 0
Sweden
State/province [412] 0 0
Falun
Country [413] 0 0
Sweden
State/province [413] 0 0
Jonkoping
Country [414] 0 0
Sweden
State/province [414] 0 0
Lidköping
Country [415] 0 0
Sweden
State/province [415] 0 0
Linkoping
Country [416] 0 0
Sweden
State/province [416] 0 0
Lund
Country [417] 0 0
Sweden
State/province [417] 0 0
Orebro
Country [418] 0 0
Sweden
State/province [418] 0 0
Skelleftea
Country [419] 0 0
Switzerland
State/province [419] 0 0
Basel
Country [420] 0 0
Switzerland
State/province [420] 0 0
Bern
Country [421] 0 0
Switzerland
State/province [421] 0 0
Fribourg
Country [422] 0 0
Switzerland
State/province [422] 0 0
Geneva 14
Country [423] 0 0
Switzerland
State/province [423] 0 0
Lausanne
Country [424] 0 0
Switzerland
State/province [424] 0 0
Lugano
Country [425] 0 0
Switzerland
State/province [425] 0 0
Zurich
Country [426] 0 0
Turkey
State/province [426] 0 0
Adana
Country [427] 0 0
Turkey
State/province [427] 0 0
Afyonkarahisar
Country [428] 0 0
Turkey
State/province [428] 0 0
Ankara
Country [429] 0 0
Turkey
State/province [429] 0 0
Corum
Country [430] 0 0
Turkey
State/province [430] 0 0
Eskisehir
Country [431] 0 0
Turkey
State/province [431] 0 0
Istanbul
Country [432] 0 0
Turkey
State/province [432] 0 0
Izmir
Country [433] 0 0
Turkey
State/province [433] 0 0
Kirikkale
Country [434] 0 0
Turkey
State/province [434] 0 0
Kocaeli
Country [435] 0 0
Turkey
State/province [435] 0 0
Konya
Country [436] 0 0
Turkey
State/province [436] 0 0
Mersin
Country [437] 0 0
Turkey
State/province [437] 0 0
Sakarya
Country [438] 0 0
Turkey
State/province [438] 0 0
Sivas
Country [439] 0 0
Turkey
State/province [439] 0 0
Van
Country [440] 0 0
Ukraine
State/province [440] 0 0
Dnipropetrovsk
Country [441] 0 0
Ukraine
State/province [441] 0 0
Ivano-Frankivsk
Country [442] 0 0
Ukraine
State/province [442] 0 0
Kharkiv
Country [443] 0 0
Ukraine
State/province [443] 0 0
Kyiv
Country [444] 0 0
Ukraine
State/province [444] 0 0
Lutsk
Country [445] 0 0
Ukraine
State/province [445] 0 0
Uzhgorod
Country [446] 0 0
Ukraine
State/province [446] 0 0
Vinnytsia
Country [447] 0 0
Ukraine
State/province [447] 0 0
Vinnytsya
Country [448] 0 0
Ukraine
State/province [448] 0 0
Zaporizhzhia
Country [449] 0 0
Ukraine
State/province [449] 0 0
Zaporizhzhya
Country [450] 0 0
United Kingdom
State/province [450] 0 0
Ayr
Country [451] 0 0
United Kingdom
State/province [451] 0 0
Basingstoke
Country [452] 0 0
United Kingdom
State/province [452] 0 0
Belfast
Country [453] 0 0
United Kingdom
State/province [453] 0 0
Blackpool
Country [454] 0 0
United Kingdom
State/province [454] 0 0
Corby
Country [455] 0 0
United Kingdom
State/province [455] 0 0
Cottingham
Country [456] 0 0
United Kingdom
State/province [456] 0 0
Dudley
Country [457] 0 0
United Kingdom
State/province [457] 0 0
Dundee
Country [458] 0 0
United Kingdom
State/province [458] 0 0
Exeter
Country [459] 0 0
United Kingdom
State/province [459] 0 0
Gillingham
Country [460] 0 0
United Kingdom
State/province [460] 0 0
Glasgow
Country [461] 0 0
United Kingdom
State/province [461] 0 0
Harlow
Country [462] 0 0
United Kingdom
State/province [462] 0 0
High Wycombe
Country [463] 0 0
United Kingdom
State/province [463] 0 0
London
Country [464] 0 0
United Kingdom
State/province [464] 0 0
Merthyr Tydfil
Country [465] 0 0
United Kingdom
State/province [465] 0 0
Newport
Country [466] 0 0
United Kingdom
State/province [466] 0 0
Northampton
Country [467] 0 0
United Kingdom
State/province [467] 0 0
Northwood
Country [468] 0 0
United Kingdom
State/province [468] 0 0
Norwich
Country [469] 0 0
United Kingdom
State/province [469] 0 0
Peterborough
Country [470] 0 0
United Kingdom
State/province [470] 0 0
Portsmouth
Country [471] 0 0
United Kingdom
State/province [471] 0 0
Romford
Country [472] 0 0
United Kingdom
State/province [472] 0 0
Sheffield
Country [473] 0 0
United Kingdom
State/province [473] 0 0
Shipley
Country [474] 0 0
United Kingdom
State/province [474] 0 0
Sidcup
Country [475] 0 0
United Kingdom
State/province [475] 0 0
Solihull
Country [476] 0 0
United Kingdom
State/province [476] 0 0
Stevenage
Country [477] 0 0
United Kingdom
State/province [477] 0 0
Sunderland
Country [478] 0 0
United Kingdom
State/province [478] 0 0
Swindon
Country [479] 0 0
United Kingdom
State/province [479] 0 0
Taunton
Country [480] 0 0
United Kingdom
State/province [480] 0 0
Torquay
Country [481] 0 0
United Kingdom
State/province [481] 0 0
Worcester

Funding & Sponsors
Primary sponsor type
Commercial sector/industry
Name
Cytokinetics
Address
Country

Ethics approval
Ethics application status

Summary
Brief summary
The purpose of this study is to determine if treatment with omecamtiv mecarbil when added to standard of care is well tolerated and superior to placebo in reducing the risk of cardiovascular death or heart failure events in adults with chronic heart failure with reduced ejection fraction (HFrEF).
Trial website
https://clinicaltrials.gov/study/NCT02929329
Trial related presentations / publications
Teerlink JR, Diaz R, Felker GM, McMurray JJV, Metra M, Solomon SD, Biering-Sorensen T, Bohm M, Bonderman D, Fang JC, Lanfear DE, Lund M, Momomura SI, O'Meara E, Ponikowski P, Spinar J, Flores-Arredondo JH, Claggett BL, Heitner SB, Kupfer S, Abbasi SA, Malik FI; GALACTIC-HF Investigators. Effect of Ejection Fraction on Clinical Outcomes in Patients Treated With Omecamtiv Mecarbil in GALACTIC-HF. J Am Coll Cardiol. 2021 Jul 13;78(2):97-108. doi: 10.1016/j.jacc.2021.04.065. Epub 2021 May 17.
Solomon SD, Claggett BL, Miao ZM, Diaz R, Felker GM, McMurray JJV, Metra M, Corbalan R, Filippatos G, Goudev AR, Mareev V, Serpytis P, Suter T, Yilmaz MB, Zannad F, Kupfer S, Heitner SB, Malik FI, Teerlink JR. Influence of atrial fibrillation on efficacy and safety of omecamtiv mecarbil in heart failure: the GALACTIC-HF trial. Eur Heart J. 2022 Jun 14;43(23):2212-2220. doi: 10.1093/eurheartj/ehac144. Erratum In: Eur Heart J. 2022 Aug 7;43(30):2903. doi: 10.1093/eurheartj/ehac332.
Felker GM, Solomon SD, Claggett B, Diaz R, McMurray JJV, Metra M, Anand I, Crespo-Leiro MG, Dahlstrom U, Goncalvesova E, Howlett JG, MacDonald P, Parkhomenko A, Tomcsanyi J, Abbasi SA, Heitner SB, Hucko T, Kupfer S, Malik FI, Teerlink JR. Assessment of Omecamtiv Mecarbil for the Treatment of Patients With Severe Heart Failure: A Post Hoc Analysis of Data From the GALACTIC-HF Randomized Clinical Trial. JAMA Cardiol. 2022 Jan 1;7(1):26-34. doi: 10.1001/jamacardio.2021.4027.
Teerlink JR, Diaz R, Felker GM, McMurray JJV, Metra M, Solomon SD, Adams KF, Anand I, Arias-Mendoza A, Biering-Sorensen T, Bohm M, Bonderman D, Cleland JGF, Corbalan R, Crespo-Leiro MG, Dahlstrom U, Echeverria LE, Fang JC, Filippatos G, Fonseca C, Goncalvesova E, Goudev AR, Howlett JG, Lanfear DE, Li J, Lund M, Macdonald P, Mareev V, Momomura SI, O'Meara E, Parkhomenko A, Ponikowski P, Ramires FJA, Serpytis P, Sliwa K, Spinar J, Suter TM, Tomcsanyi J, Vandekerckhove H, Vinereanu D, Voors AA, Yilmaz MB, Zannad F, Sharpsten L, Legg JC, Varin C, Honarpour N, Abbasi SA, Malik FI, Kurtz CE; GALACTIC-HF Investigators. Cardiac Myosin Activation with Omecamtiv Mecarbil in Systolic Heart Failure. N Engl J Med. 2021 Jan 14;384(2):105-116. doi: 10.1056/NEJMoa2025797. Epub 2020 Nov 13.
Teerlink JR, Diaz R, Felker GM, McMurray JJV, Metra M, Solomon SD, Legg JC, Buchele G, Varin C, Kurtz CE, Malik FI, Honarpour N. Omecamtiv Mecarbil in Chronic Heart Failure With Reduced Ejection Fraction: Rationale and Design of GALACTIC-HF. JACC Heart Fail. 2020 Apr;8(4):329-340. doi: 10.1016/j.jchf.2019.12.001. Epub 2020 Feb 6.
Public notes

Contacts
Principal investigator
Name 0 0
MD
Address 0 0
Amgen
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for public queries
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for scientific queries



Summary Results

For IPD and results data, please see https://clinicaltrials.gov/study/NCT02929329