Please note that the copy function is not enabled for this field.
If you wish to
modify
existing outcomes, please copy and paste the current outcome text into the Update field.
LOGIN
CREATE ACCOUNT
LOGIN
CREATE ACCOUNT
MY TRIALS
REGISTER TRIAL
FAQs
HINTS AND TIPS
DEFINITIONS
Trial Review
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been endorsed by the ANZCTR. Before participating in a study, talk to your health care provider and refer to this
information for consumers
Download to PDF
Trial details imported from ClinicalTrials.gov
For full trial details, please see the original record at
https://clinicaltrials.gov/study/NCT06252649
Registration number
NCT06252649
Ethics application status
Date submitted
15/01/2024
Date registered
12/02/2024
Date last updated
14/07/2025
Titles & IDs
Public title
Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
Query!
Scientific title
Phase 3 Multicenter, Randomized, Open-label, Active-controlled Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb for Treatment-naïve Subjects With Metastatic Colorectal Cancer With KRAS p.G12C Mutation (CodeBreaK 301)
Query!
Secondary ID [1]
0
0
20210081
Query!
Universal Trial Number (UTN)
Query!
Trial acronym
CodeBreaK 301
Query!
Linked study record
Query!
Health condition
Health condition(s) or problem(s) studied:
Metastatic Colorectal Cancer
0
0
Query!
Condition category
Condition code
Cancer
0
0
0
0
Query!
Bowel - Back passage (rectum) or large bowel (colon)
Query!
Intervention/exposure
Study type
Interventional
Query!
Description of intervention(s) / exposure
Treatment: Drugs - FOLFIRI Regimen
Treatment: Drugs - Sotorasib
Treatment: Drugs - Panitumumab
Treatment: Drugs - Bevacizumab-awwb
Experimental: Arm A: Sotorasib + Panitumumab + FOLFIRI - Sotorasib was taken daily (QD) as an oral tablet. Panitumumab and FOLFIRI were received every 2 weeks (Q2W) via intravenous infusion (IV).
Active comparator: Arm B: FOLFIRI with or Without Bevacizumab-awwb - Participants received FOLFIRI Q2W with or without bevacizumab-awwb.
Treatment: Drugs: FOLFIRI Regimen
Combination of irinotecan, leucovorin, and 5-fluorouracil given intravenously Q2W.
Treatment: Drugs: Sotorasib
Immediate-release solid dosage form administered PO.
Treatment: Drugs: Panitumumab
Administered IV Q2W.
Treatment: Drugs: Bevacizumab-awwb
Administered IV Q2W.
Query!
Intervention code [1]
0
0
Treatment: Drugs
Query!
Comparator / control treatment
Query!
Control group
Query!
Outcomes
Primary outcome [1]
0
0
PFS per Response Evaluation Criteria in Solid Tumors (RECIST v1.1)
Query!
Assessment method [1]
0
0
Query!
Timepoint [1]
0
0
Up to Approximately 3 Years
Query!
Secondary outcome [1]
0
0
Overall Survival (OS)
Query!
Assessment method [1]
0
0
Query!
Timepoint [1]
0
0
Up to Approximately 5 Years
Query!
Secondary outcome [2]
0
0
Objective Response (OR) per RECIST v1.1
Query!
Assessment method [2]
0
0
Query!
Timepoint [2]
0
0
Up to Approximately 3 Years
Query!
Secondary outcome [3]
0
0
Duration of Response (DOR) per RECIST v1.1
Query!
Assessment method [3]
0
0
Query!
Timepoint [3]
0
0
Up to Approximately 3 Years
Query!
Secondary outcome [4]
0
0
Disease Control Rate (DCR) per RECIST v1.1
Query!
Assessment method [4]
0
0
Query!
Timepoint [4]
0
0
up to Approximately 3 Years
Query!
Secondary outcome [5]
0
0
Time to Response (TTR) per RECIST v1.1
Query!
Assessment method [5]
0
0
Query!
Timepoint [5]
0
0
Up to approximately 3 Years
Query!
Secondary outcome [6]
0
0
Depth of Response per RECIST v1.1
Query!
Assessment method [6]
0
0
Depth of response is measured as the percentage of tumor shrinkage calculated as the best percentage change from baseline in lesion sum diameters.
Query!
Timepoint [6]
0
0
Up to Approximately 3 Years
Query!
Secondary outcome [7]
0
0
Time to Early Tumor Shrinkage (ETS) per RECIST v1.1
Query!
Assessment method [7]
0
0
Query!
Timepoint [7]
0
0
Up to Approximately 3 Years
Query!
Secondary outcome [8]
0
0
PFS Based on Investigator's Assessment per RECIST v1.1
Query!
Assessment method [8]
0
0
Query!
Timepoint [8]
0
0
Up to Approximately 3 Years
Query!
Secondary outcome [9]
0
0
Objective Response Rate (ORR) Based on Investigator's Assessment per RECIST v1.1
Query!
Assessment method [9]
0
0
Query!
Timepoint [9]
0
0
Up to Approximately 3 years
Query!
Secondary outcome [10]
0
0
DOR Based on Investigator's Assessment per RECIST v1.1
Query!
Assessment method [10]
0
0
Query!
Timepoint [10]
0
0
up to Approximately 3 Years
Query!
Secondary outcome [11]
0
0
DCR Based on Investigator's Assessment per RECIST v1.1
Query!
Assessment method [11]
0
0
Query!
Timepoint [11]
0
0
Up to Approximately 3 Years
Query!
Secondary outcome [12]
0
0
TTR Based on Investigator's Assessment per RECIST v1.1
Query!
Assessment method [12]
0
0
Query!
Timepoint [12]
0
0
Up to Approximately 3 Years
Query!
Secondary outcome [13]
0
0
Depth of Response Based on Investigator's Assessment per RECIST v1.1
Query!
Assessment method [13]
0
0
Query!
Timepoint [13]
0
0
Up to Approximately 3 Years
Query!
Secondary outcome [14]
0
0
Time to ETS Based on Investigator's Assessment per RECIST v1.1
Query!
Assessment method [14]
0
0
Query!
Timepoint [14]
0
0
Up to Approximately 3 Years
Query!
Secondary outcome [15]
0
0
Number of Participants Experiencing Adverse Events (AEs)
Query!
Assessment method [15]
0
0
An AE is defined as any untoward medical occurrence in participant or clinical investigation subject administered a pharmaceutical product, which does not necessarily have to have a causal relationship with this treatment. A serious AE is defined as any AE that results in death, is life threatening, requires inpatient hospitalization or prolongation of existing hospitalization, results in persistent or significant disability/incapacity, is a congenital abnormality/birth defect or important medical events that do not meet the preceding criteria but based on appropriate medical judgment may jeopardize the patient or may require medical or surgical intervention to prevent any of the outcomes listed above.
Query!
Timepoint [15]
0
0
Up to Approximately 3 Years
Query!
Secondary outcome [16]
0
0
Pre-dose (Ctrough) Concentrations of Sotorasib
Query!
Assessment method [16]
0
0
Query!
Timepoint [16]
0
0
Day 1 (pre-dose) to week 4 (post dose) on cycle 2 (one cycle = 28 days)
Query!
Secondary outcome [17]
0
0
Maximum Plasma Concentration (Cmax) of Sotorasib
Query!
Assessment method [17]
0
0
Query!
Timepoint [17]
0
0
Day 1 (pre-dose) to week 4 (post dose) on cycle 2 (one cycle = 28 days)
Query!
Eligibility
Key inclusion criteria
* Pathologically documented metastatic colorectal adenocarcinoma with KRAS p.G12C mutation by a locally validated assay.
* Central confirmation of KRAS p.G12C mutation
* Measurable metastatic disease per RECIST v1.1 criteria.
* Eastern Cooperative Oncology Group (ECOG) Performance Status of = 1.
* Adequate organ function.
Query!
Minimum age
18
Years
Query!
Query!
Maximum age
No limit
Query!
Query!
Sex
Both males and females
Query!
Can healthy volunteers participate?
No
Query!
Key exclusion criteria
* Active, untreated brain metastases.
* Leptomeningeal disease
* Previous treatment with a KRAS p.G12C inhibitor
* History of interstitial pneumonitis or pulmonary fibrosis or evidence of interstitial pneumonitis or pulmonary fibrosis on baseline CT scan
Query!
Study design
Purpose of the study
Treatment
Query!
Allocation to intervention
Randomised controlled trial
Query!
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Query!
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Query!
Masking / blinding
Open (masking not used)
Query!
Who is / are masked / blinded?
Query!
Query!
Query!
Query!
Intervention assignment
Parallel
Query!
Other design features
Query!
Phase
Phase 3
Query!
Type of endpoint/s
Query!
Statistical methods / analysis
Query!
Recruitment
Recruitment status
Recruiting
Query!
Data analysis
Query!
Reason for early stopping/withdrawal
Query!
Other reasons
Query!
Date of first participant enrolment
Anticipated
Query!
Actual
17/07/2024
Query!
Date of last participant enrolment
Anticipated
Query!
Actual
Query!
Date of last data collection
Anticipated
31/08/2031
Query!
Actual
Query!
Sample size
Target
450
Query!
Accrual to date
Query!
Final
Query!
Recruitment in Australia
Recruitment state(s)
NSW,QLD,SA,VIC
Query!
Recruitment hospital [1]
0
0
Chris OBrien Lifehouse - Camperdown
Query!
Recruitment hospital [2]
0
0
Toowoomba Hospital - Toowoomba
Query!
Recruitment hospital [3]
0
0
Flinders Medical Centre - Bedford Park
Query!
Recruitment hospital [4]
0
0
The Queen Elizabeth Hospital - Woodville South
Query!
Recruitment hospital [5]
0
0
Austin Health, Austin Hospital - Heidelberg
Query!
Recruitment postcode(s) [1]
0
0
2050 - Camperdown
Query!
Recruitment postcode(s) [2]
0
0
4350 - Toowoomba
Query!
Recruitment postcode(s) [3]
0
0
5042 - Bedford Park
Query!
Recruitment postcode(s) [4]
0
0
5011 - Woodville South
Query!
Recruitment postcode(s) [5]
0
0
3084 - Heidelberg
Query!
Recruitment outside Australia
Country [1]
0
0
United States of America
Query!
State/province [1]
0
0
Arizona
Query!
Country [2]
0
0
United States of America
Query!
State/province [2]
0
0
California
Query!
Country [3]
0
0
United States of America
Query!
State/province [3]
0
0
Connecticut
Query!
Country [4]
0
0
United States of America
Query!
State/province [4]
0
0
Florida
Query!
Country [5]
0
0
United States of America
Query!
State/province [5]
0
0
Georgia
Query!
Country [6]
0
0
United States of America
Query!
State/province [6]
0
0
Illinois
Query!
Country [7]
0
0
United States of America
Query!
State/province [7]
0
0
Kentucky
Query!
Country [8]
0
0
United States of America
Query!
State/province [8]
0
0
Michigan
Query!
Country [9]
0
0
United States of America
Query!
State/province [9]
0
0
Missouri
Query!
Country [10]
0
0
United States of America
Query!
State/province [10]
0
0
New Jersey
Query!
Country [11]
0
0
United States of America
Query!
State/province [11]
0
0
North Carolina
Query!
Country [12]
0
0
United States of America
Query!
State/province [12]
0
0
Pennsylvania
Query!
Country [13]
0
0
United States of America
Query!
State/province [13]
0
0
South Carolina
Query!
Country [14]
0
0
United States of America
Query!
State/province [14]
0
0
Tennessee
Query!
Country [15]
0
0
Argentina
Query!
State/province [15]
0
0
Buenos Aires
Query!
Country [16]
0
0
Argentina
Query!
State/province [16]
0
0
Córdoba
Query!
Country [17]
0
0
Argentina
Query!
State/province [17]
0
0
Río Negro
Query!
Country [18]
0
0
Argentina
Query!
State/province [18]
0
0
Tucuman
Query!
Country [19]
0
0
Argentina
Query!
State/province [19]
0
0
La Rioja
Query!
Country [20]
0
0
Austria
Query!
State/province [20]
0
0
Graz
Query!
Country [21]
0
0
Austria
Query!
State/province [21]
0
0
Linz
Query!
Country [22]
0
0
Austria
Query!
State/province [22]
0
0
Rankweil
Query!
Country [23]
0
0
Austria
Query!
State/province [23]
0
0
Wien
Query!
Country [24]
0
0
Belgium
Query!
State/province [24]
0
0
Brussels
Query!
Country [25]
0
0
Belgium
Query!
State/province [25]
0
0
Bruxelles
Query!
Country [26]
0
0
Belgium
Query!
State/province [26]
0
0
Charleroi
Query!
Country [27]
0
0
Belgium
Query!
State/province [27]
0
0
Gent
Query!
Country [28]
0
0
Belgium
Query!
State/province [28]
0
0
Leuven
Query!
Country [29]
0
0
Belgium
Query!
State/province [29]
0
0
Mechelen
Query!
Country [30]
0
0
Belgium
Query!
State/province [30]
0
0
Roeselare
Query!
Country [31]
0
0
Belgium
Query!
State/province [31]
0
0
Sint-Niklaas
Query!
Country [32]
0
0
Brazil
Query!
State/province [32]
0
0
Distrito Federal
Query!
Country [33]
0
0
Brazil
Query!
State/province [33]
0
0
Espírito Santo
Query!
Country [34]
0
0
Brazil
Query!
State/province [34]
0
0
Piauí
Query!
Country [35]
0
0
Brazil
Query!
State/province [35]
0
0
Rio Grande Do Norte
Query!
Country [36]
0
0
Brazil
Query!
State/province [36]
0
0
Rio Grande Do Sul
Query!
Country [37]
0
0
Brazil
Query!
State/province [37]
0
0
Santa Catarina
Query!
Country [38]
0
0
Brazil
Query!
State/province [38]
0
0
São Paulo
Query!
Country [39]
0
0
Brazil
Query!
State/province [39]
0
0
Rio de Janeiro
Query!
Country [40]
0
0
Bulgaria
Query!
State/province [40]
0
0
Haskovo
Query!
Country [41]
0
0
Bulgaria
Query!
State/province [41]
0
0
Plovdiv
Query!
Country [42]
0
0
Bulgaria
Query!
State/province [42]
0
0
Sofia
Query!
Country [43]
0
0
Chile
Query!
State/province [43]
0
0
Cautín
Query!
Country [44]
0
0
Chile
Query!
State/province [44]
0
0
Santiago
Query!
Country [45]
0
0
Chile
Query!
State/province [45]
0
0
Valdivia
Query!
Country [46]
0
0
Colombia
Query!
State/province [46]
0
0
Antioquia
Query!
Country [47]
0
0
Colombia
Query!
State/province [47]
0
0
Cundinamarca
Query!
Country [48]
0
0
Colombia
Query!
State/province [48]
0
0
Córdoba
Query!
Country [49]
0
0
Colombia
Query!
State/province [49]
0
0
Santander
Query!
Country [50]
0
0
Czechia
Query!
State/province [50]
0
0
Brno
Query!
Country [51]
0
0
Czechia
Query!
State/province [51]
0
0
Hradec Kralove
Query!
Country [52]
0
0
Czechia
Query!
State/province [52]
0
0
Olomouc
Query!
Country [53]
0
0
Czechia
Query!
State/province [53]
0
0
Praha 10
Query!
Country [54]
0
0
Czechia
Query!
State/province [54]
0
0
Praha 5
Query!
Country [55]
0
0
Denmark
Query!
State/province [55]
0
0
Aalborg
Query!
Country [56]
0
0
Denmark
Query!
State/province [56]
0
0
Aarhus N
Query!
Country [57]
0
0
Denmark
Query!
State/province [57]
0
0
Copenhagen
Query!
Country [58]
0
0
Denmark
Query!
State/province [58]
0
0
Odense C
Query!
Country [59]
0
0
Estonia
Query!
State/province [59]
0
0
Tallinn
Query!
Country [60]
0
0
France
Query!
State/province [60]
0
0
Clermont-Ferrand cedex 1
Query!
Country [61]
0
0
France
Query!
State/province [61]
0
0
Creteil
Query!
Country [62]
0
0
France
Query!
State/province [62]
0
0
Dijon Cedex
Query!
Country [63]
0
0
France
Query!
State/province [63]
0
0
Lyon
Query!
Country [64]
0
0
France
Query!
State/province [64]
0
0
Montpellier Cedex 5
Query!
Country [65]
0
0
France
Query!
State/province [65]
0
0
Nice
Query!
Country [66]
0
0
France
Query!
State/province [66]
0
0
Paris Cedex 10
Query!
Country [67]
0
0
France
Query!
State/province [67]
0
0
Paris Cedex 13
Query!
Country [68]
0
0
France
Query!
State/province [68]
0
0
Paris
Query!
Country [69]
0
0
France
Query!
State/province [69]
0
0
Pessac
Query!
Country [70]
0
0
France
Query!
State/province [70]
0
0
Poitiers Cedex
Query!
Country [71]
0
0
France
Query!
State/province [71]
0
0
Reims
Query!
Country [72]
0
0
France
Query!
State/province [72]
0
0
Rennes Cedex 9
Query!
Country [73]
0
0
France
Query!
State/province [73]
0
0
Saint Priest en Jarez
Query!
Country [74]
0
0
France
Query!
State/province [74]
0
0
Saint-Herblain Cedex
Query!
Country [75]
0
0
France
Query!
State/province [75]
0
0
Vandoeuvre les Nancy Cedex
Query!
Country [76]
0
0
Germany
Query!
State/province [76]
0
0
Berlin
Query!
Country [77]
0
0
Germany
Query!
State/province [77]
0
0
Chemnitz
Query!
Country [78]
0
0
Germany
Query!
State/province [78]
0
0
Dresden
Query!
Country [79]
0
0
Germany
Query!
State/province [79]
0
0
Essen
Query!
Country [80]
0
0
Germany
Query!
State/province [80]
0
0
Frankfurt am Main
Query!
Country [81]
0
0
Germany
Query!
State/province [81]
0
0
Hamburg
Query!
Country [82]
0
0
Germany
Query!
State/province [82]
0
0
Ludwigsburg
Query!
Country [83]
0
0
Germany
Query!
State/province [83]
0
0
Muenchen
Query!
Country [84]
0
0
Germany
Query!
State/province [84]
0
0
Ulm
Query!
Country [85]
0
0
Germany
Query!
State/province [85]
0
0
Wolfsburg
Query!
Country [86]
0
0
Greece
Query!
State/province [86]
0
0
Athens
Query!
Country [87]
0
0
Greece
Query!
State/province [87]
0
0
Larissa
Query!
Country [88]
0
0
Greece
Query!
State/province [88]
0
0
Piraeus
Query!
Country [89]
0
0
Greece
Query!
State/province [89]
0
0
Thessaloniki
Query!
Country [90]
0
0
Hong Kong
Query!
State/province [90]
0
0
Hong Kong
Query!
Country [91]
0
0
Hong Kong
Query!
State/province [91]
0
0
Kowloon
Query!
Country [92]
0
0
Hungary
Query!
State/province [92]
0
0
Budapest
Query!
Country [93]
0
0
Hungary
Query!
State/province [93]
0
0
Debrecen
Query!
Country [94]
0
0
Hungary
Query!
State/province [94]
0
0
Gyula
Query!
Country [95]
0
0
Hungary
Query!
State/province [95]
0
0
Kaposvar
Query!
Country [96]
0
0
Hungary
Query!
State/province [96]
0
0
Nyiregyhaza
Query!
Country [97]
0
0
Hungary
Query!
State/province [97]
0
0
Szolnok
Query!
Country [98]
0
0
Italy
Query!
State/province [98]
0
0
Brescia
Query!
Country [99]
0
0
Italy
Query!
State/province [99]
0
0
Castellana Grotte
Query!
Country [100]
0
0
Italy
Query!
State/province [100]
0
0
Firenze
Query!
Country [101]
0
0
Italy
Query!
State/province [101]
0
0
Foggia
Query!
Country [102]
0
0
Italy
Query!
State/province [102]
0
0
Genova
Query!
Country [103]
0
0
Italy
Query!
State/province [103]
0
0
Milano
Query!
Country [104]
0
0
Italy
Query!
State/province [104]
0
0
Palermo
Query!
Country [105]
0
0
Italy
Query!
State/province [105]
0
0
Pesaro
Query!
Country [106]
0
0
Italy
Query!
State/province [106]
0
0
Pisa
Query!
Country [107]
0
0
Italy
Query!
State/province [107]
0
0
Udine
Query!
Country [108]
0
0
Italy
Query!
State/province [108]
0
0
Verona
Query!
Country [109]
0
0
Japan
Query!
State/province [109]
0
0
Aichi
Query!
Country [110]
0
0
Japan
Query!
State/province [110]
0
0
Chiba
Query!
Country [111]
0
0
Japan
Query!
State/province [111]
0
0
Ehime
Query!
Country [112]
0
0
Japan
Query!
State/province [112]
0
0
Fukuoka
Query!
Country [113]
0
0
Japan
Query!
State/province [113]
0
0
Hokkaido
Query!
Country [114]
0
0
Japan
Query!
State/province [114]
0
0
Hyogo
Query!
Country [115]
0
0
Japan
Query!
State/province [115]
0
0
Kanagawa
Query!
Country [116]
0
0
Japan
Query!
State/province [116]
0
0
Niigata
Query!
Country [117]
0
0
Japan
Query!
State/province [117]
0
0
Osaka
Query!
Country [118]
0
0
Japan
Query!
State/province [118]
0
0
Saitama
Query!
Country [119]
0
0
Japan
Query!
State/province [119]
0
0
Shizuoka
Query!
Country [120]
0
0
Japan
Query!
State/province [120]
0
0
Tokushima
Query!
Country [121]
0
0
Japan
Query!
State/province [121]
0
0
Tokyo
Query!
Country [122]
0
0
Korea, Republic of
Query!
State/province [122]
0
0
Goyang-si, Gyeonggi-do
Query!
Country [123]
0
0
Korea, Republic of
Query!
State/province [123]
0
0
Seoul
Query!
Country [124]
0
0
Mexico
Query!
State/province [124]
0
0
Distrito Federal
Query!
Country [125]
0
0
Mexico
Query!
State/province [125]
0
0
Nuevo León
Query!
Country [126]
0
0
Netherlands
Query!
State/province [126]
0
0
Amsterdam
Query!
Country [127]
0
0
Netherlands
Query!
State/province [127]
0
0
Enschede
Query!
Country [128]
0
0
Poland
Query!
State/province [128]
0
0
Kielce
Query!
Country [129]
0
0
Poland
Query!
State/province [129]
0
0
Opole
Query!
Country [130]
0
0
Poland
Query!
State/province [130]
0
0
Poznan
Query!
Country [131]
0
0
Poland
Query!
State/province [131]
0
0
Warszawa
Query!
Country [132]
0
0
Portugal
Query!
State/province [132]
0
0
Almada
Query!
Country [133]
0
0
Portugal
Query!
State/province [133]
0
0
Coimbra
Query!
Country [134]
0
0
Portugal
Query!
State/province [134]
0
0
Lisboa
Query!
Country [135]
0
0
Portugal
Query!
State/province [135]
0
0
Matosinhos
Query!
Country [136]
0
0
Portugal
Query!
State/province [136]
0
0
Santa Maria da Feira
Query!
Country [137]
0
0
Romania
Query!
State/province [137]
0
0
Bucharest
Query!
Country [138]
0
0
Romania
Query!
State/province [138]
0
0
Bucuresti
Query!
Country [139]
0
0
Romania
Query!
State/province [139]
0
0
Cluj Napoca
Query!
Country [140]
0
0
Romania
Query!
State/province [140]
0
0
Craiova
Query!
Country [141]
0
0
Romania
Query!
State/province [141]
0
0
Iasi
Query!
Country [142]
0
0
Romania
Query!
State/province [142]
0
0
Ploiesti
Query!
Country [143]
0
0
Romania
Query!
State/province [143]
0
0
Timisoara
Query!
Country [144]
0
0
Spain
Query!
State/province [144]
0
0
Andalucía
Query!
Country [145]
0
0
Spain
Query!
State/province [145]
0
0
Asturias
Query!
Country [146]
0
0
Spain
Query!
State/province [146]
0
0
Cantabria
Query!
Country [147]
0
0
Spain
Query!
State/province [147]
0
0
Castilla León
Query!
Country [148]
0
0
Spain
Query!
State/province [148]
0
0
Cataluña
Query!
Country [149]
0
0
Spain
Query!
State/province [149]
0
0
Comunidad Valenciana
Query!
Country [150]
0
0
Spain
Query!
State/province [150]
0
0
Galicia
Query!
Country [151]
0
0
Spain
Query!
State/province [151]
0
0
Navarra
Query!
Country [152]
0
0
Spain
Query!
State/province [152]
0
0
Madrid
Query!
Country [153]
0
0
Sweden
Query!
State/province [153]
0
0
Stockholm
Query!
Country [154]
0
0
Switzerland
Query!
State/province [154]
0
0
Zuerich
Query!
Country [155]
0
0
Taiwan
Query!
State/province [155]
0
0
Taichung
Query!
Country [156]
0
0
Taiwan
Query!
State/province [156]
0
0
Taipei
Query!
Country [157]
0
0
Taiwan
Query!
State/province [157]
0
0
Taoyuan
Query!
Country [158]
0
0
Thailand
Query!
State/province [158]
0
0
Bangkok
Query!
Country [159]
0
0
Turkey
Query!
State/province [159]
0
0
Adana
Query!
Country [160]
0
0
Turkey
Query!
State/province [160]
0
0
Ankara
Query!
Country [161]
0
0
Turkey
Query!
State/province [161]
0
0
Edirne
Query!
Country [162]
0
0
Turkey
Query!
State/province [162]
0
0
Istanbul
Query!
Country [163]
0
0
Turkey
Query!
State/province [163]
0
0
Izmir
Query!
Country [164]
0
0
Turkey
Query!
State/province [164]
0
0
Konya
Query!
Country [165]
0
0
Turkey
Query!
State/province [165]
0
0
Malatya
Query!
Country [166]
0
0
United Kingdom
Query!
State/province [166]
0
0
London
Query!
Country [167]
0
0
United Kingdom
Query!
State/province [167]
0
0
Maidstone
Query!
Country [168]
0
0
United Kingdom
Query!
State/province [168]
0
0
Northwood
Query!
Funding & Sponsors
Primary sponsor type
Commercial sector/industry
Query!
Name
Amgen
Query!
Address
Query!
Country
Query!
Ethics approval
Ethics application status
Query!
Summary
Brief summary
The aim of this study is to compare progression free survival (PFS) in treatment-naïve Participants with KRAS p.G12C mutated metastatic colorectal cancer (mCRC) receiving sotorasib, panitumumab and FOLFIRI vs FOLFIRI with or without bevacizumab-awwb.
Query!
Trial website
https://clinicaltrials.gov/study/NCT06252649
Query!
Trial related presentations / publications
Query!
Public notes
Query!
Contacts
Principal investigator
Name
0
0
MD
Query!
Address
0
0
Amgen
Query!
Country
0
0
Query!
Phone
0
0
Query!
Fax
0
0
Query!
Email
0
0
Query!
Contact person for public queries
Name
0
0
Amgen Call Center
Query!
Address
0
0
Query!
Country
0
0
Query!
Phone
0
0
866-572-6436
Query!
Fax
0
0
Query!
Email
0
0
[email protected]
Query!
Contact person for scientific queries
Data sharing statement
What supporting documents are/will be available?
No Supporting Document Provided
Results publications and other study-related documents
No documents have been uploaded by study researchers.
Results not provided in
https://clinicaltrials.gov/study/NCT06252649
Download to PDF