Trial Review

Did you know?

The ANZCTR now automatically displays published trial results and simplifies the addition of trial documents such as unpublished protocols and statistical analysis plans.

These enhancements will offer a more comprehensive view of trials, regardless of whether their results are positive, negative, or inconclusive.

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been endorsed by the ANZCTR. Before participating in a study, talk to your health care provider and refer to this information for consumers
Trial details imported from ClinicalTrials.gov

For full trial details, please see the original record at https://clinicaltrials.gov/study/NCT00699998




Registration number
NCT00699998
Ethics application status
Date submitted
16/06/2008
Date registered
18/06/2008
Date last updated
7/05/2013

Titles & IDs
Public title
A Comparison of Prasugrel and Clopidogrel in Acute Coronary Syndrome Subjects
Scientific title
A Comparison of Prasugrel and Clopidogrel in Acute Coronary Syndrome Subjects With Unstable Angina/Non-ST-Elevation Myocardial Infarction Who Are Medically Managed
Secondary ID [1] 0 0
H7T-MC-TABY(b)
Secondary ID [2] 0 0
11058
Universal Trial Number (UTN)
Trial acronym
TRILOGY ACS
Linked study record

Health condition
Health condition(s) or problem(s) studied:
Acute Coronary Syndrome 0 0
Condition category
Condition code
Cardiovascular 0 0 0 0
Coronary heart disease
Other 0 0 0 0
Research that is not of generic health relevance and not applicable to specific health categories listed above

Intervention/exposure
Study type
Interventional
Description of intervention(s) / exposure
Treatment: Drugs - Clopidogrel
Treatment: Drugs - Prasugrel
Treatment: Drugs - Commercially-available Aspirin

Experimental: Prasugrel - Prasugrel and Low-dose Commercially-available Aspirin

Active comparator: Clopidogrel - Clopidogrel and Low-Dose Commercially-available Aspirin


Treatment: Drugs: Clopidogrel
300 milligrams (mg), oral, once as loading dose (in those subjects who initiate study drug with a loading dose); and 75 mg, oral, once daily as maintenance dose through end of study

Treatment: Drugs: Prasugrel
30 milligrams (mg), oral, once as loading dose (in those subjects who initiate study drug with a loading dose); and either 5 mg or 10 mg (based upon weight and age), oral, once daily as maintenance dose through end of study

Treatment: Drugs: Commercially-available Aspirin
Low-dose aspirin, oral, as prescribed by physician through end of study
Intervention code [1] 0 0
Treatment: Drugs
Comparator / control treatment
Control group

Outcomes
Primary outcome [1] 0 0
Percentage of Participants With a Composite Endpoint of Cardiovascular (CV) Death, Myocardial Infarction (MI), or Stroke
Timepoint [1] 0 0
Randomization through end of study (30-month visit)
Secondary outcome [1] 0 0
Percentage of Participants With a Composite Endpoint of CV Death and MI
Timepoint [1] 0 0
Randomization through end of study (30-month visit)
Secondary outcome [2] 0 0
Percentage of Participants With a Composite Endpoint of CV Death, MI, Stroke, or Re-hospitalization for Recurrent Unstable Angina (UA)
Timepoint [2] 0 0
Randomization through end of study (30-month visit)
Secondary outcome [3] 0 0
Percentage of Participants With a Composite Endpoint of All-cause Death, MI, or Stroke
Timepoint [3] 0 0
Randomization through end of study (30-month visit)
Secondary outcome [4] 0 0
Platelet Aggregation Measures
Timepoint [4] 0 0
Day 30 and 12 Months
Secondary outcome [5] 0 0
Biomarker Measurements of Inflammation/Hemodynamic Stress: Brain Natriuretic Peptide (BNP)
Timepoint [5] 0 0
Day 30 and 6 Months
Secondary outcome [6] 0 0
Biomarker Measurements of Inflammation/Hemodynamic Stress: C-Reactive Protein (CRP)
Timepoint [6] 0 0
Day 30 and Month 6
Secondary outcome [7] 0 0
Genotyping Related to Drug Metabolism
Timepoint [7] 0 0
Baseline
Secondary outcome [8] 0 0
Economic and Quality of Life Outcomes
Timepoint [8] 0 0
Baseline and follow-up (24 months)
Secondary outcome [9] 0 0
Summary of All Deaths
Timepoint [9] 0 0
Randomization through end of study (30-month visit)

Eligibility
Key inclusion criteria
Key

* Have had a Unstable Angina/Non-ST-Elevation Myocardial Infarction (UA/NSTEMI) index event within 10 days prior to randomization
* Had a medical management strategy decision made with reasonable certainty that neither percutaneous coronary intervention (PCI) nor coronary artery bypass graft (CABG) is planned for treatment of the index event
* Had at least 1 of 4 specified high-risk features at the time of the UA/NSTEMI event

Key
Minimum age
18 Years
Maximum age
No limit
Sex
Both males and females
Can healthy volunteers participate?
No
Key exclusion criteria
* Decision for medical management greater than 72 hours after onset of index event without commercial clopidogrel treatment within 72 hours following onset of the index event.
* Insignificant coronary artery disease (CAD) on coronary angiography if performed for Index Event (absence of greater than or equal to 30% stenosis in at least one native vessel)
* Previous or planned PCI or CABG as treatment for the index event
* PCI/CABG within previous 30 days
* ST-segment elevation myocardial infarction (STEMI) as the index event
* Cardiogenic shock, Refractory ventricular arrhythmias, New York Heart Association (NYHA) Class IV congestive heart failure (CHF) within the previous 24 hours
* History of ischemic or hemorrhagic stroke, transient ischemic attack (TIA), Intracranial neoplasm, arteriovenous malformation, or aneurysm
* History of spontaneous gastrointestinal (GI) or non-GI bleeding requiring hospitalization for treatment, unless definitive treatment has occurred and there is low likelihood of recurrence
* Hemodialysis or peritoneal dialysis

Study design
Purpose of the study
Treatment
Allocation to intervention
Randomised controlled trial
Procedure for enrolling a subject and allocating the treatment (allocation concealment procedures)
Methods used to generate the sequence in which subjects will be randomised (sequence generation)
Masking / blinding
Blinded (masking used)
Who is / are masked / blinded?
The people receiving the treatment/s
The people administering the treatment/s
The people assessing the outcomes
The people analysing the results/data
Intervention assignment
Parallel
Other design features
Phase
Phase 3
Type of endpoint/s
Statistical methods / analysis

Recruitment
Recruitment status
Completed
Data analysis
Reason for early stopping/withdrawal
Other reasons
Date of first participant enrolment
Anticipated
Actual
1/06/2008
Date of last participant enrolment
Anticipated
Actual
Date of last data collection
Anticipated
Actual
1/04/2012
Sample size
Target
Accrual to date
Final
9326
Recruitment in Australia
Recruitment state(s)
NSW,QLD,SA,TAS
Recruitment hospital [1] 0 0
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. - Coffs Harbour
Recruitment hospital [2] 0 0
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. - Lismore
Recruitment hospital [3] 0 0
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. - Newcastle
Recruitment hospital [4] 0 0
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. - Wollongong
Recruitment hospital [5] 0 0
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. - Herston
Recruitment hospital [6] 0 0
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. - Nambour
Recruitment hospital [7] 0 0
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. - Redcliffe
Recruitment hospital [8] 0 0
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. - Southport
Recruitment hospital [9] 0 0
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. - Bedford Park
Recruitment hospital [10] 0 0
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. - Elizabeth Vale
Recruitment hospital [11] 0 0
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. - Hobart
Recruitment postcode(s) [1] 0 0
2450 - Coffs Harbour
Recruitment postcode(s) [2] 0 0
2480 - Lismore
Recruitment postcode(s) [3] 0 0
2305 - Newcastle
Recruitment postcode(s) [4] 0 0
2500 - Wollongong
Recruitment postcode(s) [5] 0 0
4029 - Herston
Recruitment postcode(s) [6] 0 0
4560 - Nambour
Recruitment postcode(s) [7] 0 0
4020 - Redcliffe
Recruitment postcode(s) [8] 0 0
4215 - Southport
Recruitment postcode(s) [9] 0 0
5042 - Bedford Park
Recruitment postcode(s) [10] 0 0
5112 - Elizabeth Vale
Recruitment postcode(s) [11] 0 0
7000 - Hobart
Recruitment outside Australia
Country [1] 0 0
United States of America
State/province [1] 0 0
Alabama
Country [2] 0 0
United States of America
State/province [2] 0 0
Arizona
Country [3] 0 0
United States of America
State/province [3] 0 0
Arkansas
Country [4] 0 0
United States of America
State/province [4] 0 0
California
Country [5] 0 0
United States of America
State/province [5] 0 0
Colorado
Country [6] 0 0
United States of America
State/province [6] 0 0
District of Columbia
Country [7] 0 0
United States of America
State/province [7] 0 0
Florida
Country [8] 0 0
United States of America
State/province [8] 0 0
Georgia
Country [9] 0 0
United States of America
State/province [9] 0 0
Illinois
Country [10] 0 0
United States of America
State/province [10] 0 0
Indiana
Country [11] 0 0
United States of America
State/province [11] 0 0
Iowa
Country [12] 0 0
United States of America
State/province [12] 0 0
Kentucky
Country [13] 0 0
United States of America
State/province [13] 0 0
Louisiana
Country [14] 0 0
United States of America
State/province [14] 0 0
Maryland
Country [15] 0 0
United States of America
State/province [15] 0 0
Massachusetts
Country [16] 0 0
United States of America
State/province [16] 0 0
Michigan
Country [17] 0 0
United States of America
State/province [17] 0 0
Minnesota
Country [18] 0 0
United States of America
State/province [18] 0 0
Mississippi
Country [19] 0 0
United States of America
State/province [19] 0 0
Missouri
Country [20] 0 0
United States of America
State/province [20] 0 0
Montana
Country [21] 0 0
United States of America
State/province [21] 0 0
Nebraska
Country [22] 0 0
United States of America
State/province [22] 0 0
Nevada
Country [23] 0 0
United States of America
State/province [23] 0 0
New Hampshire
Country [24] 0 0
United States of America
State/province [24] 0 0
New Jersey
Country [25] 0 0
United States of America
State/province [25] 0 0
New York
Country [26] 0 0
United States of America
State/province [26] 0 0
North Carolina
Country [27] 0 0
United States of America
State/province [27] 0 0
Ohio
Country [28] 0 0
United States of America
State/province [28] 0 0
Oklahoma
Country [29] 0 0
United States of America
State/province [29] 0 0
Oregon
Country [30] 0 0
United States of America
State/province [30] 0 0
Pennsylvania
Country [31] 0 0
United States of America
State/province [31] 0 0
South Carolina
Country [32] 0 0
United States of America
State/province [32] 0 0
South Dakota
Country [33] 0 0
United States of America
State/province [33] 0 0
Tennessee
Country [34] 0 0
United States of America
State/province [34] 0 0
Texas
Country [35] 0 0
United States of America
State/province [35] 0 0
Utah
Country [36] 0 0
United States of America
State/province [36] 0 0
Virginia
Country [37] 0 0
United States of America
State/province [37] 0 0
Washington
Country [38] 0 0
United States of America
State/province [38] 0 0
Wisconsin
Country [39] 0 0
Argentina
State/province [39] 0 0
Bahia Blanca
Country [40] 0 0
Argentina
State/province [40] 0 0
Buenos Aires
Country [41] 0 0
Argentina
State/province [41] 0 0
Caba
Country [42] 0 0
Argentina
State/province [42] 0 0
Concordia
Country [43] 0 0
Argentina
State/province [43] 0 0
Corrientes
Country [44] 0 0
Argentina
State/province [44] 0 0
Córdoba
Country [45] 0 0
Argentina
State/province [45] 0 0
Formosa
Country [46] 0 0
Argentina
State/province [46] 0 0
Godoy Cruz
Country [47] 0 0
Argentina
State/province [47] 0 0
La Plata
Country [48] 0 0
Argentina
State/province [48] 0 0
Mar Del Plata
Country [49] 0 0
Argentina
State/province [49] 0 0
Moron
Country [50] 0 0
Argentina
State/province [50] 0 0
Rosario
Country [51] 0 0
Argentina
State/province [51] 0 0
Salta
Country [52] 0 0
Argentina
State/province [52] 0 0
San Luis
Country [53] 0 0
Argentina
State/province [53] 0 0
San Miguel De Tucuman
Country [54] 0 0
Argentina
State/province [54] 0 0
Santa Fe
Country [55] 0 0
Argentina
State/province [55] 0 0
Villa Cabrera
Country [56] 0 0
Argentina
State/province [56] 0 0
Villa Maria
Country [57] 0 0
Austria
State/province [57] 0 0
Feldkirch
Country [58] 0 0
Austria
State/province [58] 0 0
Vienna
Country [59] 0 0
Belgium
State/province [59] 0 0
Brussels
Country [60] 0 0
Belgium
State/province [60] 0 0
Huy
Country [61] 0 0
Belgium
State/province [61] 0 0
Liège
Country [62] 0 0
Belgium
State/province [62] 0 0
Mol
Country [63] 0 0
Belgium
State/province [63] 0 0
Overpelt
Country [64] 0 0
Brazil
State/province [64] 0 0
Aracaju
Country [65] 0 0
Brazil
State/province [65] 0 0
Belo Horizonte
Country [66] 0 0
Brazil
State/province [66] 0 0
Blumenau
Country [67] 0 0
Brazil
State/province [67] 0 0
Brasilia
Country [68] 0 0
Brazil
State/province [68] 0 0
Campina Grande Do Sul
Country [69] 0 0
Brazil
State/province [69] 0 0
Campinas
Country [70] 0 0
Brazil
State/province [70] 0 0
Campo Grande
Country [71] 0 0
Brazil
State/province [71] 0 0
Caxias Do Sul
Country [72] 0 0
Brazil
State/province [72] 0 0
Curitiba
Country [73] 0 0
Brazil
State/province [73] 0 0
Dois Lajeados
Country [74] 0 0
Brazil
State/province [74] 0 0
Goiania
Country [75] 0 0
Brazil
State/province [75] 0 0
Maceio
Country [76] 0 0
Brazil
State/province [76] 0 0
Maringa
Country [77] 0 0
Brazil
State/province [77] 0 0
Passo Fundo
Country [78] 0 0
Brazil
State/province [78] 0 0
Piracicaba
Country [79] 0 0
Brazil
State/province [79] 0 0
Porto Alegre
Country [80] 0 0
Brazil
State/province [80] 0 0
Recife
Country [81] 0 0
Brazil
State/province [81] 0 0
Ribeirao Preto
Country [82] 0 0
Brazil
State/province [82] 0 0
Rio De Janeiro
Country [83] 0 0
Brazil
State/province [83] 0 0
Salvador
Country [84] 0 0
Brazil
State/province [84] 0 0
Santo Andre
Country [85] 0 0
Brazil
State/province [85] 0 0
Sao Caetano Do Sul
Country [86] 0 0
Brazil
State/province [86] 0 0
Sao Jose Rio Preto
Country [87] 0 0
Brazil
State/province [87] 0 0
Sao Jose
Country [88] 0 0
Brazil
State/province [88] 0 0
São Paulo
Country [89] 0 0
Brazil
State/province [89] 0 0
Uberlandia
Country [90] 0 0
Brazil
State/province [90] 0 0
Votuporanga
Country [91] 0 0
Bulgaria
State/province [91] 0 0
Dimitrovgrad
Country [92] 0 0
Bulgaria
State/province [92] 0 0
Haskovo
Country [93] 0 0
Bulgaria
State/province [93] 0 0
Kazanlak
Country [94] 0 0
Bulgaria
State/province [94] 0 0
Kjustendil
Country [95] 0 0
Bulgaria
State/province [95] 0 0
Pazardzhik
Country [96] 0 0
Bulgaria
State/province [96] 0 0
Pleven
Country [97] 0 0
Bulgaria
State/province [97] 0 0
Plovdiv
Country [98] 0 0
Bulgaria
State/province [98] 0 0
Rousse
Country [99] 0 0
Bulgaria
State/province [99] 0 0
Sofia
Country [100] 0 0
Bulgaria
State/province [100] 0 0
Varna
Country [101] 0 0
Canada
State/province [101] 0 0
Alberta
Country [102] 0 0
Canada
State/province [102] 0 0
British Columbia
Country [103] 0 0
Canada
State/province [103] 0 0
Newfoundland and Labrador
Country [104] 0 0
Canada
State/province [104] 0 0
Nova Scotia
Country [105] 0 0
Canada
State/province [105] 0 0
Ontario
Country [106] 0 0
Canada
State/province [106] 0 0
Quebec
Country [107] 0 0
Chile
State/province [107] 0 0
La Serena
Country [108] 0 0
Chile
State/province [108] 0 0
Osorno
Country [109] 0 0
Chile
State/province [109] 0 0
Puente Alto
Country [110] 0 0
Chile
State/province [110] 0 0
Rancagua
Country [111] 0 0
Chile
State/province [111] 0 0
Santiago
Country [112] 0 0
Chile
State/province [112] 0 0
Temuco
Country [113] 0 0
Chile
State/province [113] 0 0
Vina Del Mar
Country [114] 0 0
China
State/province [114] 0 0
Beijing
Country [115] 0 0
China
State/province [115] 0 0
Bejing
Country [116] 0 0
China
State/province [116] 0 0
Changsha
Country [117] 0 0
China
State/province [117] 0 0
Fuzhou
Country [118] 0 0
China
State/province [118] 0 0
Guang Zhou
Country [119] 0 0
China
State/province [119] 0 0
Hangzhou
Country [120] 0 0
China
State/province [120] 0 0
Harbin
Country [121] 0 0
China
State/province [121] 0 0
Jiangsu
Country [122] 0 0
China
State/province [122] 0 0
Nanchang
Country [123] 0 0
China
State/province [123] 0 0
Nanjing
Country [124] 0 0
China
State/province [124] 0 0
Shanghai
Country [125] 0 0
China
State/province [125] 0 0
Shaoguan
Country [126] 0 0
China
State/province [126] 0 0
Shengyang
Country [127] 0 0
China
State/province [127] 0 0
Shenyang
Country [128] 0 0
China
State/province [128] 0 0
Shijiazhuang
Country [129] 0 0
China
State/province [129] 0 0
Suzhou City
Country [130] 0 0
China
State/province [130] 0 0
Wenzhou
Country [131] 0 0
China
State/province [131] 0 0
Wu Han
Country [132] 0 0
China
State/province [132] 0 0
Wuhan City
Country [133] 0 0
China
State/province [133] 0 0
Xian
Country [134] 0 0
China
State/province [134] 0 0
Xuzhou
Country [135] 0 0
China
State/province [135] 0 0
Zhengzhou
Country [136] 0 0
Colombia
State/province [136] 0 0
Armenia-Quindio
Country [137] 0 0
Colombia
State/province [137] 0 0
Barranquilla
Country [138] 0 0
Colombia
State/province [138] 0 0
Bogota
Country [139] 0 0
Colombia
State/province [139] 0 0
Cali
Country [140] 0 0
Colombia
State/province [140] 0 0
Floridablanca
Country [141] 0 0
Colombia
State/province [141] 0 0
Medellin
Country [142] 0 0
Costa Rica
State/province [142] 0 0
San Jose
Country [143] 0 0
Croatia
State/province [143] 0 0
Dubrovnik
Country [144] 0 0
Croatia
State/province [144] 0 0
Karlovac
Country [145] 0 0
Croatia
State/province [145] 0 0
Koprivnica
Country [146] 0 0
Croatia
State/province [146] 0 0
Krapinske Toplice
Country [147] 0 0
Croatia
State/province [147] 0 0
Rijeka
Country [148] 0 0
Croatia
State/province [148] 0 0
Slavonski Brod
Country [149] 0 0
Croatia
State/province [149] 0 0
Split
Country [150] 0 0
Croatia
State/province [150] 0 0
Varazdin
Country [151] 0 0
Croatia
State/province [151] 0 0
Zadar
Country [152] 0 0
Croatia
State/province [152] 0 0
Zagreb
Country [153] 0 0
Czech Republic
State/province [153] 0 0
Decin
Country [154] 0 0
Czech Republic
State/province [154] 0 0
Frydek-Mistek
Country [155] 0 0
Czech Republic
State/province [155] 0 0
Hradec Kralove
Country [156] 0 0
Czech Republic
State/province [156] 0 0
Karlovy Vary
Country [157] 0 0
Czech Republic
State/province [157] 0 0
Kromeriz
Country [158] 0 0
Czech Republic
State/province [158] 0 0
Liberec
Country [159] 0 0
Czech Republic
State/province [159] 0 0
Novy Jicin
Country [160] 0 0
Czech Republic
State/province [160] 0 0
Pardubice
Country [161] 0 0
Czech Republic
State/province [161] 0 0
Prague
Country [162] 0 0
Czech Republic
State/province [162] 0 0
Zlin
Country [163] 0 0
Denmark
State/province [163] 0 0
Copenhagen
Country [164] 0 0
Denmark
State/province [164] 0 0
Hellerup
Country [165] 0 0
Denmark
State/province [165] 0 0
Kobenhavn
Country [166] 0 0
Egypt
State/province [166] 0 0
Alexandria
Country [167] 0 0
Egypt
State/province [167] 0 0
Beni Sweif
Country [168] 0 0
Egypt
State/province [168] 0 0
Cairo
Country [169] 0 0
Egypt
State/province [169] 0 0
Ismailia
Country [170] 0 0
Egypt
State/province [170] 0 0
Menoufiya
Country [171] 0 0
Finland
State/province [171] 0 0
Jyvaskyla
Country [172] 0 0
France
State/province [172] 0 0
Angers
Country [173] 0 0
France
State/province [173] 0 0
Arras
Country [174] 0 0
France
State/province [174] 0 0
Besancon
Country [175] 0 0
France
State/province [175] 0 0
Cambrai
Country [176] 0 0
France
State/province [176] 0 0
Chartres Cedex
Country [177] 0 0
France
State/province [177] 0 0
Dijon
Country [178] 0 0
France
State/province [178] 0 0
Douai
Country [179] 0 0
France
State/province [179] 0 0
La Roche Sur Yon
Country [180] 0 0
France
State/province [180] 0 0
Lagny Sur Marne
Country [181] 0 0
France
State/province [181] 0 0
Nantes
Country [182] 0 0
France
State/province [182] 0 0
Nice
Country [183] 0 0
France
State/province [183] 0 0
Paris
Country [184] 0 0
France
State/province [184] 0 0
Pessac
Country [185] 0 0
France
State/province [185] 0 0
Poitiers
Country [186] 0 0
France
State/province [186] 0 0
Strasbourg
Country [187] 0 0
France
State/province [187] 0 0
Toulouse
Country [188] 0 0
France
State/province [188] 0 0
Valenciennes
Country [189] 0 0
France
State/province [189] 0 0
Vandoeuvre Les Nancy
Country [190] 0 0
Germany
State/province [190] 0 0
Bad Nauheim
Country [191] 0 0
Germany
State/province [191] 0 0
Darmstadt
Country [192] 0 0
Germany
State/province [192] 0 0
Dortmund
Country [193] 0 0
Germany
State/province [193] 0 0
Frankfurt
Country [194] 0 0
Germany
State/province [194] 0 0
Halle
Country [195] 0 0
Germany
State/province [195] 0 0
Idar-Oberstein
Country [196] 0 0
Germany
State/province [196] 0 0
Köln
Country [197] 0 0
Germany
State/province [197] 0 0
Leipzig
Country [198] 0 0
Germany
State/province [198] 0 0
Mainz
Country [199] 0 0
Germany
State/province [199] 0 0
Mannheim
Country [200] 0 0
Germany
State/province [200] 0 0
Stuttgart
Country [201] 0 0
Germany
State/province [201] 0 0
Tuebingen
Country [202] 0 0
Greece
State/province [202] 0 0
Athens
Country [203] 0 0
Greece
State/province [203] 0 0
Haidari/Athens
Country [204] 0 0
Greece
State/province [204] 0 0
Kallithea
Country [205] 0 0
Greece
State/province [205] 0 0
Magoula
Country [206] 0 0
Greece
State/province [206] 0 0
Patras
Country [207] 0 0
Greece
State/province [207] 0 0
Rhodos
Country [208] 0 0
Greece
State/province [208] 0 0
Trikala
Country [209] 0 0
Hungary
State/province [209] 0 0
Baja
Country [210] 0 0
Hungary
State/province [210] 0 0
Bekescsaba
Country [211] 0 0
Hungary
State/province [211] 0 0
Budapest
Country [212] 0 0
Hungary
State/province [212] 0 0
Kalocsa
Country [213] 0 0
Hungary
State/province [213] 0 0
Kecskemet
Country [214] 0 0
Hungary
State/province [214] 0 0
Komarom
Country [215] 0 0
Hungary
State/province [215] 0 0
Miskolc
Country [216] 0 0
Hungary
State/province [216] 0 0
Satoraljaujhely
Country [217] 0 0
Hungary
State/province [217] 0 0
Sopron
Country [218] 0 0
Hungary
State/province [218] 0 0
Szekszard
Country [219] 0 0
Hungary
State/province [219] 0 0
Zalaegerszeg
Country [220] 0 0
India
State/province [220] 0 0
Ahmedabad
Country [221] 0 0
India
State/province [221] 0 0
Anand
Country [222] 0 0
India
State/province [222] 0 0
Aurangabad
Country [223] 0 0
India
State/province [223] 0 0
Bangalore
Country [224] 0 0
India
State/province [224] 0 0
Baramati
Country [225] 0 0
India
State/province [225] 0 0
Bikaner
Country [226] 0 0
India
State/province [226] 0 0
Calicut
Country [227] 0 0
India
State/province [227] 0 0
Chidambaram
Country [228] 0 0
India
State/province [228] 0 0
Cochin
Country [229] 0 0
India
State/province [229] 0 0
Coimbatore
Country [230] 0 0
India
State/province [230] 0 0
Ernakulam
Country [231] 0 0
India
State/province [231] 0 0
Guntur
Country [232] 0 0
India
State/province [232] 0 0
Gurgaon
Country [233] 0 0
India
State/province [233] 0 0
Hyderabaad
Country [234] 0 0
India
State/province [234] 0 0
Indore
Country [235] 0 0
India
State/province [235] 0 0
Jaipur
Country [236] 0 0
India
State/province [236] 0 0
Jalandhar
Country [237] 0 0
India
State/province [237] 0 0
Kolkata
Country [238] 0 0
India
State/province [238] 0 0
Kottayam
Country [239] 0 0
India
State/province [239] 0 0
Lucknow
Country [240] 0 0
India
State/province [240] 0 0
Madurai
Country [241] 0 0
India
State/province [241] 0 0
Mumbai
Country [242] 0 0
India
State/province [242] 0 0
Mysore
Country [243] 0 0
India
State/province [243] 0 0
Nagpur
Country [244] 0 0
India
State/province [244] 0 0
Nashik
Country [245] 0 0
India
State/province [245] 0 0
New Delhi
Country [246] 0 0
India
State/province [246] 0 0
Patiala
Country [247] 0 0
India
State/province [247] 0 0
Pune
Country [248] 0 0
India
State/province [248] 0 0
Saket
Country [249] 0 0
India
State/province [249] 0 0
Secunderabad
Country [250] 0 0
India
State/province [250] 0 0
Shivamogga
Country [251] 0 0
India
State/province [251] 0 0
Solapur
Country [252] 0 0
India
State/province [252] 0 0
Surat
Country [253] 0 0
India
State/province [253] 0 0
Thrissur
Country [254] 0 0
India
State/province [254] 0 0
Tirupati
Country [255] 0 0
India
State/province [255] 0 0
Trivandrum
Country [256] 0 0
India
State/province [256] 0 0
Vadodara
Country [257] 0 0
India
State/province [257] 0 0
Vijayawada
Country [258] 0 0
India
State/province [258] 0 0
Visakhapatnam
Country [259] 0 0
Ireland
State/province [259] 0 0
Dublin
Country [260] 0 0
Ireland
State/province [260] 0 0
Galway
Country [261] 0 0
Israel
State/province [261] 0 0
Afula
Country [262] 0 0
Israel
State/province [262] 0 0
Ashkelon
Country [263] 0 0
Israel
State/province [263] 0 0
Beer Sheva
Country [264] 0 0
Israel
State/province [264] 0 0
Eilat
Country [265] 0 0
Israel
State/province [265] 0 0
Haifa
Country [266] 0 0
Israel
State/province [266] 0 0
Jerusalem
Country [267] 0 0
Israel
State/province [267] 0 0
Kfar Saba
Country [268] 0 0
Israel
State/province [268] 0 0
Nahariya
Country [269] 0 0
Israel
State/province [269] 0 0
Nazareth
Country [270] 0 0
Israel
State/province [270] 0 0
Rehovot
Country [271] 0 0
Israel
State/province [271] 0 0
Tel Aviv
Country [272] 0 0
Israel
State/province [272] 0 0
Tel Hashomer
Country [273] 0 0
Israel
State/province [273] 0 0
Tiberias
Country [274] 0 0
Israel
State/province [274] 0 0
Tzfat
Country [275] 0 0
Italy
State/province [275] 0 0
Albano Laziale
Country [276] 0 0
Italy
State/province [276] 0 0
Ascoli Piceno
Country [277] 0 0
Italy
State/province [277] 0 0
Bari
Country [278] 0 0
Italy
State/province [278] 0 0
Bergamo
Country [279] 0 0
Italy
State/province [279] 0 0
Brescia
Country [280] 0 0
Italy
State/province [280] 0 0
Caserta
Country [281] 0 0
Italy
State/province [281] 0 0
Forli
Country [282] 0 0
Italy
State/province [282] 0 0
Lecco
Country [283] 0 0
Italy
State/province [283] 0 0
Legnago
Country [284] 0 0
Italy
State/province [284] 0 0
Legnano
Country [285] 0 0
Italy
State/province [285] 0 0
Milano
Country [286] 0 0
Italy
State/province [286] 0 0
Novara
Country [287] 0 0
Italy
State/province [287] 0 0
Parma
Country [288] 0 0
Italy
State/province [288] 0 0
Perugia
Country [289] 0 0
Italy
State/province [289] 0 0
Pescara
Country [290] 0 0
Italy
State/province [290] 0 0
Reggio Emilia
Country [291] 0 0
Italy
State/province [291] 0 0
Rimini
Country [292] 0 0
Italy
State/province [292] 0 0
Rome
Country [293] 0 0
Italy
State/province [293] 0 0
San Daniele Del Friuli
Country [294] 0 0
Italy
State/province [294] 0 0
Santa Maria Capua Vetere
Country [295] 0 0
Italy
State/province [295] 0 0
Saronno
Country [296] 0 0
Italy
State/province [296] 0 0
Sorrento
Country [297] 0 0
Italy
State/province [297] 0 0
Terni
Country [298] 0 0
Italy
State/province [298] 0 0
Trieste
Country [299] 0 0
Korea, Republic of
State/province [299] 0 0
Busan
Country [300] 0 0
Korea, Republic of
State/province [300] 0 0
Daegu
Country [301] 0 0
Korea, Republic of
State/province [301] 0 0
Daejeon
Country [302] 0 0
Korea, Republic of
State/province [302] 0 0
Gangwon-Do
Country [303] 0 0
Korea, Republic of
State/province [303] 0 0
Gwangju
Country [304] 0 0
Korea, Republic of
State/province [304] 0 0
Incheon
Country [305] 0 0
Korea, Republic of
State/province [305] 0 0
Jeon Ju-City
Country [306] 0 0
Korea, Republic of
State/province [306] 0 0
Jin-Ju-Si
Country [307] 0 0
Korea, Republic of
State/province [307] 0 0
Seoul
Country [308] 0 0
Korea, Republic of
State/province [308] 0 0
Ulsan-Si
Country [309] 0 0
Lithuania
State/province [309] 0 0
Kaunas
Country [310] 0 0
Lithuania
State/province [310] 0 0
Klaipeda
Country [311] 0 0
Lithuania
State/province [311] 0 0
Siauliai
Country [312] 0 0
Lithuania
State/province [312] 0 0
Vilnius
Country [313] 0 0
Malaysia
State/province [313] 0 0
Cheras, Kuala Lumpur
Country [314] 0 0
Malaysia
State/province [314] 0 0
Johor Bahru
Country [315] 0 0
Malaysia
State/province [315] 0 0
Kelantan
Country [316] 0 0
Malaysia
State/province [316] 0 0
Kuala Lumpur
Country [317] 0 0
Malaysia
State/province [317] 0 0
Kuantan Pahang
Country [318] 0 0
Malaysia
State/province [318] 0 0
Perak
Country [319] 0 0
Malaysia
State/province [319] 0 0
Sarawak
Country [320] 0 0
Malaysia
State/province [320] 0 0
Selangor
Country [321] 0 0
Malaysia
State/province [321] 0 0
Taiping Perak
Country [322] 0 0
Malta
State/province [322] 0 0
Gozo
Country [323] 0 0
Malta
State/province [323] 0 0
Msida
Country [324] 0 0
Mexico
State/province [324] 0 0
Aguascalientes
Country [325] 0 0
Mexico
State/province [325] 0 0
Culiacan
Country [326] 0 0
Mexico
State/province [326] 0 0
Durango
Country [327] 0 0
Mexico
State/province [327] 0 0
Jalisco
Country [328] 0 0
Mexico
State/province [328] 0 0
Leon
Country [329] 0 0
Mexico
State/province [329] 0 0
Monterrey
Country [330] 0 0
Mexico
State/province [330] 0 0
Puebla
Country [331] 0 0
Mexico
State/province [331] 0 0
Queretaro
Country [332] 0 0
Mexico
State/province [332] 0 0
San Luis Potosi
Country [333] 0 0
Mexico
State/province [333] 0 0
Tijuana
Country [334] 0 0
Netherlands
State/province [334] 0 0
Alkmaar
Country [335] 0 0
Netherlands
State/province [335] 0 0
Almelo
Country [336] 0 0
Netherlands
State/province [336] 0 0
Amsterdam
Country [337] 0 0
Netherlands
State/province [337] 0 0
Apeldoorn
Country [338] 0 0
Netherlands
State/province [338] 0 0
Beverwijk
Country [339] 0 0
Netherlands
State/province [339] 0 0
Blaricum
Country [340] 0 0
Netherlands
State/province [340] 0 0
Delft
Country [341] 0 0
Netherlands
State/province [341] 0 0
Ede
Country [342] 0 0
Netherlands
State/province [342] 0 0
Eindhoven
Country [343] 0 0
Netherlands
State/province [343] 0 0
Gouda
Country [344] 0 0
Netherlands
State/province [344] 0 0
Hoorn
Country [345] 0 0
Netherlands
State/province [345] 0 0
Leeuwarden
Country [346] 0 0
Netherlands
State/province [346] 0 0
Leiden
Country [347] 0 0
Netherlands
State/province [347] 0 0
Leiderdorp
Country [348] 0 0
Netherlands
State/province [348] 0 0
Meppel
Country [349] 0 0
Netherlands
State/province [349] 0 0
Oss
Country [350] 0 0
Netherlands
State/province [350] 0 0
Roosendaal
Country [351] 0 0
Netherlands
State/province [351] 0 0
Venlo
Country [352] 0 0
New Zealand
State/province [352] 0 0
Auckland
Country [353] 0 0
New Zealand
State/province [353] 0 0
Christchurch
Country [354] 0 0
New Zealand
State/province [354] 0 0
Nelson
Country [355] 0 0
New Zealand
State/province [355] 0 0
Wellington
Country [356] 0 0
Panama
State/province [356] 0 0
Cocle
Country [357] 0 0
Panama
State/province [357] 0 0
David
Country [358] 0 0
Panama
State/province [358] 0 0
Panama
Country [359] 0 0
Peru
State/province [359] 0 0
Arequipa
Country [360] 0 0
Peru
State/province [360] 0 0
Callao
Country [361] 0 0
Peru
State/province [361] 0 0
Cuzco
Country [362] 0 0
Peru
State/province [362] 0 0
Lima
Country [363] 0 0
Philippines
State/province [363] 0 0
Cagayan De De Oro
Country [364] 0 0
Philippines
State/province [364] 0 0
Cavite City
Country [365] 0 0
Philippines
State/province [365] 0 0
Davao City
Country [366] 0 0
Philippines
State/province [366] 0 0
Iloilo City
Country [367] 0 0
Philippines
State/province [367] 0 0
Manila
Country [368] 0 0
Philippines
State/province [368] 0 0
Marikina City
Country [369] 0 0
Philippines
State/province [369] 0 0
Metro Manila
Country [370] 0 0
Philippines
State/province [370] 0 0
Pasig City
Country [371] 0 0
Philippines
State/province [371] 0 0
Quezon City
Country [372] 0 0
Poland
State/province [372] 0 0
Bydgoszcz
Country [373] 0 0
Poland
State/province [373] 0 0
Elblag
Country [374] 0 0
Poland
State/province [374] 0 0
Gdansk
Country [375] 0 0
Poland
State/province [375] 0 0
Katowice
Country [376] 0 0
Poland
State/province [376] 0 0
Koszalin
Country [377] 0 0
Poland
State/province [377] 0 0
Krakow
Country [378] 0 0
Poland
State/province [378] 0 0
Kutno
Country [379] 0 0
Poland
State/province [379] 0 0
Lodz
Country [380] 0 0
Poland
State/province [380] 0 0
Lubin
Country [381] 0 0
Poland
State/province [381] 0 0
Lublin
Country [382] 0 0
Poland
State/province [382] 0 0
Myslenice
Country [383] 0 0
Poland
State/province [383] 0 0
Nowy Sacz
Country [384] 0 0
Poland
State/province [384] 0 0
Olawa
Country [385] 0 0
Poland
State/province [385] 0 0
Piotrkow Trybunalski
Country [386] 0 0
Poland
State/province [386] 0 0
Pulawy
Country [387] 0 0
Poland
State/province [387] 0 0
Ruda Slaska
Country [388] 0 0
Poland
State/province [388] 0 0
Skierniewice
Country [389] 0 0
Poland
State/province [389] 0 0
Szczecin
Country [390] 0 0
Poland
State/province [390] 0 0
Walbrzych
Country [391] 0 0
Poland
State/province [391] 0 0
Warsaw
Country [392] 0 0
Poland
State/province [392] 0 0
Wejherowo
Country [393] 0 0
Poland
State/province [393] 0 0
Wroclaw
Country [394] 0 0
Portugal
State/province [394] 0 0
Aveiro
Country [395] 0 0
Portugal
State/province [395] 0 0
Carnaxide
Country [396] 0 0
Portugal
State/province [396] 0 0
Coimbra
Country [397] 0 0
Portugal
State/province [397] 0 0
Leiria
Country [398] 0 0
Portugal
State/province [398] 0 0
Ponta Delgada
Country [399] 0 0
Portugal
State/province [399] 0 0
Santarem
Country [400] 0 0
Portugal
State/province [400] 0 0
Setubal
Country [401] 0 0
Portugal
State/province [401] 0 0
Vila Franca De Xira
Country [402] 0 0
Puerto Rico
State/province [402] 0 0
Caguas
Country [403] 0 0
Puerto Rico
State/province [403] 0 0
Mayaguez
Country [404] 0 0
Puerto Rico
State/province [404] 0 0
San Juan
Country [405] 0 0
Romania
State/province [405] 0 0
Bacau
Country [406] 0 0
Romania
State/province [406] 0 0
Baia Mare
Country [407] 0 0
Romania
State/province [407] 0 0
Braila
Country [408] 0 0
Romania
State/province [408] 0 0
Brasov
Country [409] 0 0
Romania
State/province [409] 0 0
Bucharest
Country [410] 0 0
Romania
State/province [410] 0 0
Buzau
Country [411] 0 0
Romania
State/province [411] 0 0
Cluj-Napoca
Country [412] 0 0
Romania
State/province [412] 0 0
Focsani
Country [413] 0 0
Romania
State/province [413] 0 0
Pitesti
Country [414] 0 0
Romania
State/province [414] 0 0
Suceava
Country [415] 0 0
Romania
State/province [415] 0 0
Targoviste
Country [416] 0 0
Russian Federation
State/province [416] 0 0
Arkhangelsk
Country [417] 0 0
Russian Federation
State/province [417] 0 0
Gatchina
Country [418] 0 0
Russian Federation
State/province [418] 0 0
Kazan
Country [419] 0 0
Russian Federation
State/province [419] 0 0
Kemerovo
Country [420] 0 0
Russian Federation
State/province [420] 0 0
Krasnoyarsk
Country [421] 0 0
Russian Federation
State/province [421] 0 0
Moscow
Country [422] 0 0
Russian Federation
State/province [422] 0 0
Nizhny Novgorod
Country [423] 0 0
Russian Federation
State/province [423] 0 0
Novokuznetsk
Country [424] 0 0
Russian Federation
State/province [424] 0 0
Novosibirsk
Country [425] 0 0
Russian Federation
State/province [425] 0 0
Omsk
Country [426] 0 0
Russian Federation
State/province [426] 0 0
Rostov-On-Don
Country [427] 0 0
Russian Federation
State/province [427] 0 0
Saint Petersburg
Country [428] 0 0
Russian Federation
State/province [428] 0 0
Saratov
Country [429] 0 0
Russian Federation
State/province [429] 0 0
Tomsk
Country [430] 0 0
Russian Federation
State/province [430] 0 0
Tyumen
Country [431] 0 0
Serbia
State/province [431] 0 0
Belgrade
Country [432] 0 0
Serbia
State/province [432] 0 0
Kragujevac
Country [433] 0 0
Serbia
State/province [433] 0 0
Niska Banja
Country [434] 0 0
Serbia
State/province [434] 0 0
Nis
Country [435] 0 0
Serbia
State/province [435] 0 0
Zemun
Country [436] 0 0
Singapore
State/province [436] 0 0
Singapore
Country [437] 0 0
Slovakia
State/province [437] 0 0
Bratislava
Country [438] 0 0
Slovakia
State/province [438] 0 0
Levice
Country [439] 0 0
Slovakia
State/province [439] 0 0
Martin
Country [440] 0 0
Slovakia
State/province [440] 0 0
Nitra
Country [441] 0 0
Slovakia
State/province [441] 0 0
Nove Zamky
Country [442] 0 0
Slovakia
State/province [442] 0 0
Presov
Country [443] 0 0
Slovakia
State/province [443] 0 0
Ruzomberok
Country [444] 0 0
Slovakia
State/province [444] 0 0
Zilina
Country [445] 0 0
South Africa
State/province [445] 0 0
Alberton
Country [446] 0 0
South Africa
State/province [446] 0 0
Bloemfontein
Country [447] 0 0
South Africa
State/province [447] 0 0
Cape Town
Country [448] 0 0
South Africa
State/province [448] 0 0
Durban
Country [449] 0 0
South Africa
State/province [449] 0 0
George
Country [450] 0 0
South Africa
State/province [450] 0 0
Johannesburg
Country [451] 0 0
South Africa
State/province [451] 0 0
Parktown West
Country [452] 0 0
South Africa
State/province [452] 0 0
Somerset West
Country [453] 0 0
South Africa
State/province [453] 0 0
Worcester
Country [454] 0 0
Spain
State/province [454] 0 0
Barcelona
Country [455] 0 0
Spain
State/province [455] 0 0
Gerona
Country [456] 0 0
Spain
State/province [456] 0 0
Málaga
Country [457] 0 0
Spain
State/province [457] 0 0
Palma De Mallorca
Country [458] 0 0
Spain
State/province [458] 0 0
Reus
Country [459] 0 0
Spain
State/province [459] 0 0
San Boi De Llobregat
Country [460] 0 0
Spain
State/province [460] 0 0
Sevilla
Country [461] 0 0
Spain
State/province [461] 0 0
Valencia
Country [462] 0 0
Sweden
State/province [462] 0 0
Bollnas
Country [463] 0 0
Sweden
State/province [463] 0 0
Karlstad
Country [464] 0 0
Sweden
State/province [464] 0 0
Lund
Country [465] 0 0
Switzerland
State/province [465] 0 0
Bellinzona
Country [466] 0 0
Switzerland
State/province [466] 0 0
Winterthur
Country [467] 0 0
Taiwan
State/province [467] 0 0
Kaohsiung
Country [468] 0 0
Taiwan
State/province [468] 0 0
Taipei
Country [469] 0 0
Thailand
State/province [469] 0 0
Bangkok
Country [470] 0 0
Thailand
State/province [470] 0 0
Chiang Mai
Country [471] 0 0
Thailand
State/province [471] 0 0
Khon Kaen
Country [472] 0 0
Thailand
State/province [472] 0 0
Nakhon Ratchasima
Country [473] 0 0
Thailand
State/province [473] 0 0
Pathumthani
Country [474] 0 0
Thailand
State/province [474] 0 0
Udon Thani
Country [475] 0 0
Tunisia
State/province [475] 0 0
La Marsa
Country [476] 0 0
Tunisia
State/province [476] 0 0
Menzel Bourguiba
Country [477] 0 0
Tunisia
State/province [477] 0 0
Monastir
Country [478] 0 0
Tunisia
State/province [478] 0 0
Sfax
Country [479] 0 0
Tunisia
State/province [479] 0 0
Sousse
Country [480] 0 0
Tunisia
State/province [480] 0 0
Tunis Monfleury
Country [481] 0 0
Tunisia
State/province [481] 0 0
Tunis
Country [482] 0 0
Turkey
State/province [482] 0 0
Adana
Country [483] 0 0
Turkey
State/province [483] 0 0
Ankara
Country [484] 0 0
Turkey
State/province [484] 0 0
Bolu
Country [485] 0 0
Turkey
State/province [485] 0 0
Bursa
Country [486] 0 0
Turkey
State/province [486] 0 0
Edirne
Country [487] 0 0
Turkey
State/province [487] 0 0
Erzurum
Country [488] 0 0
Turkey
State/province [488] 0 0
Isparta
Country [489] 0 0
Turkey
State/province [489] 0 0
Istanbul
Country [490] 0 0
Turkey
State/province [490] 0 0
Kocaeli
Country [491] 0 0
Turkey
State/province [491] 0 0
Konya
Country [492] 0 0
Turkey
State/province [492] 0 0
Kirikkale
Country [493] 0 0
Turkey
State/province [493] 0 0
Samsun
Country [494] 0 0
Turkey
State/province [494] 0 0
Trabzon
Country [495] 0 0
Ukraine
State/province [495] 0 0
Cherkasy
Country [496] 0 0
Ukraine
State/province [496] 0 0
Dnipropetrovsk
Country [497] 0 0
Ukraine
State/province [497] 0 0
Donetsk
Country [498] 0 0
Ukraine
State/province [498] 0 0
Ivano-Frankivsk
Country [499] 0 0
Ukraine
State/province [499] 0 0
Kharkiv
Country [500] 0 0
Ukraine
State/province [500] 0 0
Kiev
Country [501] 0 0
Ukraine
State/province [501] 0 0
Kryvyy Rig
Country [502] 0 0
Ukraine
State/province [502] 0 0
Kyiv
Country [503] 0 0
Ukraine
State/province [503] 0 0
Lugansk
Country [504] 0 0
Ukraine
State/province [504] 0 0
Lutsk
Country [505] 0 0
Ukraine
State/province [505] 0 0
Lviv
Country [506] 0 0
Ukraine
State/province [506] 0 0
Mykolayiv
Country [507] 0 0
Ukraine
State/province [507] 0 0
Odesa
Country [508] 0 0
Ukraine
State/province [508] 0 0
Poltava
Country [509] 0 0
Ukraine
State/province [509] 0 0
Simferopol
Country [510] 0 0
Ukraine
State/province [510] 0 0
Vinnytsya
Country [511] 0 0
Ukraine
State/province [511] 0 0
Zaporozhye
Country [512] 0 0
United Kingdom
State/province [512] 0 0
Cleveland
Country [513] 0 0
United Kingdom
State/province [513] 0 0
Cnwll
Country [514] 0 0
United Kingdom
State/province [514] 0 0
County Durham
Country [515] 0 0
United Kingdom
State/province [515] 0 0
Derbyshire
Country [516] 0 0
United Kingdom
State/province [516] 0 0
Devon
Country [517] 0 0
United Kingdom
State/province [517] 0 0
East Sussex
Country [518] 0 0
United Kingdom
State/province [518] 0 0
East Yorkshire
Country [519] 0 0
United Kingdom
State/province [519] 0 0
Essex
Country [520] 0 0
United Kingdom
State/province [520] 0 0
Greater London
Country [521] 0 0
United Kingdom
State/province [521] 0 0
Gwent
Country [522] 0 0
United Kingdom
State/province [522] 0 0
Hampshire
Country [523] 0 0
United Kingdom
State/province [523] 0 0
Kent
Country [524] 0 0
United Kingdom
State/province [524] 0 0
Lincolnshire
Country [525] 0 0
United Kingdom
State/province [525] 0 0
Merseyside
Country [526] 0 0
United Kingdom
State/province [526] 0 0
North Yorkshire
Country [527] 0 0
United Kingdom
State/province [527] 0 0
Nottinghamshire
Country [528] 0 0
United Kingdom
State/province [528] 0 0
Somerset
Country [529] 0 0
United Kingdom
State/province [529] 0 0
Tays
Country [530] 0 0
United Kingdom
State/province [530] 0 0
Warwickshire
Country [531] 0 0
United Kingdom
State/province [531] 0 0
West Lothian
Country [532] 0 0
United Kingdom
State/province [532] 0 0
West Midlands
Country [533] 0 0
United Kingdom
State/province [533] 0 0
West Yorkshire
Country [534] 0 0
United Kingdom
State/province [534] 0 0
Northampton
Country [535] 0 0
United Kingdom
State/province [535] 0 0
Sunderland

Funding & Sponsors
Primary sponsor type
Commercial sector/industry
Name
Eli Lilly and Company
Address
Country
Other collaborator category [1] 0 0
Commercial sector/industry
Name [1] 0 0
Daiichi Sankyo Co., Ltd.
Address [1] 0 0
Country [1] 0 0
Other collaborator category [2] 0 0
Other
Name [2] 0 0
Duke Clinical Research Institute
Address [2] 0 0
Country [2] 0 0

Ethics approval
Ethics application status

Summary
Brief summary
This study will evaluate the relative efficacy and safety of prasugrel and clopidogrel in a medically managed Unstable Angina/Non-ST-Elevation Myocardial Infarction (UA/NSTEMI) acute coronary syndrome (ACS) population (that is, patients who are not managed with acute coronary revascularization).
Trial website
https://clinicaltrials.gov/study/NCT00699998
Trial related presentations / publications
Natale P, Palmer SC, Saglimbene VM, Ruospo M, Razavian M, Craig JC, Jardine MJ, Webster AC, Strippoli GF. Antiplatelet agents for chronic kidney disease. Cochrane Database Syst Rev. 2022 Feb 28;2(2):CD008834. doi: 10.1002/14651858.CD008834.pub4.
Marquis-Gravel G, Neely ML, Valgimigli M, Costa F, Van Klaveren D, Altner R, Bhatt DL, Armstrong PW, Fox KAA, White HD, Ohman EM, Roe MT. Long-Term Bleeding Risk Prediction with Dual Antiplatelet Therapy After Acute Coronary Syndromes Treated Without Revascularization. Circ Cardiovasc Qual Outcomes. 2020 Sep;13(9):e006582. doi: 10.1161/CIRCOUTCOMES.120.006582. Epub 2020 Aug 31.
Kaul P, Alexander KP, Ohman EM, Savu A, Roe MT, Goodman SG, Fox KA, White HD, Prabhakaran D, Hochman JS, Clemmensen P, Armstrong PW. Sex And Prognostic Significance of Self-Reported Frailty in Non-ST-Segment Elevation Acute Coronary Syndromes: Insights From the TRILOGY ACS Trial. Can J Cardiol. 2019 Apr;35(4):430-437. doi: 10.1016/j.cjca.2018.12.035. Epub 2018 Dec 31.
Fanaroff AC, Cyr D, Neely ML, Bakal J, White HD, Fox KAA, Armstrong PW, Lopes RD, Ohman EM, Roe MT. Days Alive and Out of Hospital: Exploring a Patient-Centered, Pragmatic Outcome in a Clinical Trial of Patients With Acute Coronary Syndromes. Circ Cardiovasc Qual Outcomes. 2018 Dec;11(12):e004755. doi: 10.1161/CIRCOUTCOMES.118.004755.
Inohara T, Pieper K, Wojdyla DM, Patel MR, Jones WS, Tricoci P, Mahaffey KW, James SK, Alexander JH, Lopes RD, Wallentin L, Ohman EM, Roe MT, Vemulapalli S. Incidence, timing, and type of first and recurrent ischemic events in patients with and without peripheral artery disease after an acute coronary syndrome. Am Heart J. 2018 Jul;201:25-32. doi: 10.1016/j.ahj.2018.03.013. Epub 2018 Mar 28.
Chan MY, Neely ML, Roe MT, Goodman SG, Erlinge D, Cornel JH, Winters KJ, Jakubowski JA, Zhou C, Fox KAA, Armstrong PW, White HD, Prabhakaran D, Ohman EM, Huber K; TRILOGY ACS Investigators. Temporal Biomarker Profiling Reveals Longitudinal Changes in Risk of Death or Myocardial Infarction in Non-ST-Segment Elevation Acute Coronary Syndrome. Clin Chem. 2017 Jul;63(7):1214-1226. doi: 10.1373/clinchem.2016.265272. Epub 2017 May 17.
Goldstein SA, Newby LK, Cyr DD, Neely M, Luscher TF, Brown EB, White HD, Ohman EM, Roe MT, Hamm CW. Relationship Between Peak Troponin Values and Long-Term Ischemic Events Among Medically Managed Patients With Acute Coronary Syndromes. J Am Heart Assoc. 2017 Apr 11;6(4):e005334. doi: 10.1161/JAHA.116.005334.
Alfredsson J, Neely B, Neely ML, Bhatt DL, Goodman SG, Tricoci P, Mahaffey KW, Cornel JH, White HD, Fox KA, Prabhakaran D, Winters KJ, Armstrong PW, Ohman EM, Roe MT; TRILOGY ACS Investigators. Predicting the risk of bleeding during dual antiplatelet therapy after acute coronary syndromes. Heart. 2017 Aug;103(15):1168-1176. doi: 10.1136/heartjnl-2016-310090. Epub 2017 Apr 5.
Cornel JH, Ohman EM, Neely B, Jakubowski JA, Bhatt DL, White HD, Ardissino D, Fox KA, Prabhakaran D, Armstrong PW, Erlinge D, Tantry US, Gurbel PA, Roe MT. Relationship of Platelet Reactivity With Bleeding Outcomes During Long-Term Treatment With Dual Antiplatelet Therapy for Medically Managed Patients With Non-ST-Segment Elevation Acute Coronary Syndromes. J Am Heart Assoc. 2016 Nov 4;5(11):e003977. doi: 10.1161/JAHA.116.003977.
Chin CT, Boden WE, Roe MT, Neely B, Neely ML, Leiva-Pons JL, Corbalan R, Gottlieb S, Dalby AJ, Armstrong PW, Prabhakaran D, Fox KA, White HD, Ohman EM, Winters KJ, Schiele F. Effect of prior clopidogrel use on outcomes in medically managed acute coronary syndrome patients. Heart. 2016 Aug 1;102(15):1221-9. doi: 10.1136/heartjnl-2015-308840. Epub 2016 Mar 30.
Lopes RD, Leonardi S, Neely B, Neely ML, Ohman EM, Ardissino D, Hamm CW, Goodman SG, Bhatt DL, White HD, Prabhakaran D, Martinez F, Nicolau JC, Winters KJ, Fox KA, Armstrong PW, Roe MT. Spontaneous MI After Non-ST-Segment Elevation Acute Coronary Syndrome Managed Without Revascularization: The TRILOGY ACS Trial. J Am Coll Cardiol. 2016 Mar 22;67(11):1289-97. doi: 10.1016/j.jacc.2016.01.034.
Doll JA, Neely ML, Roe MT, Armstrong PW, White HD, Prabhakaran D, Winters KJ, Duvvuru S, Sundseth SS, Jakubowski JA, Gurbel PA, Bhatt DL, Ohman EM, Fox KAA; TRILOGY ACS Investigators. Impact of CYP2C19 Metabolizer Status on Patients With ACS Treated With Prasugrel Versus Clopidogrel. J Am Coll Cardiol. 2016 Mar 1;67(8):936-947. doi: 10.1016/j.jacc.2015.12.036.
Chin CT, Neely B, Magnus Ohman E, Armstrong PW, Corbalan R, White HD, Prabhakaran D, Winters KJ, Fox KA, Roe MT; TRILOGY ACS Investigators. Time-Varying Effects of Prasugrel Versus Clopidogrel on the Long-Term Risks of Stroke After Acute Coronary Syndromes: Results From the TRILOGY ACS Trial. Stroke. 2016 Apr;47(4):1135-9. doi: 10.1161/STROKEAHA.115.012454. Epub 2016 Feb 16.
Roe MT, Cyr DD, Eckart D, Schulte PJ, Morse MA, Blackwell KL, Ready NE, Zafar SY, Beaven AW, Strickler JH, Onken JE, Winters KJ, Houterloot L, Zamoryakhin D, Wiviott SD, White HD, Prabhakaran D, Fox KA, Armstrong PW, Ohman EM; TRILOGY ACS Investigators. Ascertainment, classification, and impact of neoplasm detection during prolonged treatment with dual antiplatelet therapy with prasugrel vs. clopidogrel following acute coronary syndrome. Eur Heart J. 2016 Jan 21;37(4):412-22. doi: 10.1093/eurheartj/ehv611. Epub 2015 Dec 5.
Clemmensen P, Roe MT, Hochman JS, Cyr DD, Neely ML, McGuire DK, Cornel JH, Huber K, Zamoryakhin D, White HD, Armstrong PW, Fox KA, Prabhakaran D, Ohman EM; TRILOGY ACS Investigators. Long-term outcomes for women versus men with unstable angina/non-ST-segment elevation myocardial infarction managed medically without revascularization: insights from the TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes trial. Am Heart J. 2015 Oct;170(4):695-705.e5. doi: 10.1016/j.ahj.2015.06.011. Epub 2015 Jun 20.
Mahaffey KW, Hager R, Wojdyla D, White HD, Armstrong PW, Alexander JH, Tricoci P, Lopes RD, Ohman EM, Roe MT, Harrington RA, Wallentin L. Meta-analysis of intracranial hemorrhage in acute coronary syndromes: incidence, predictors, and clinical outcomes. J Am Heart Assoc. 2015 Jun 18;4(6):e001512. doi: 10.1161/JAHA.114.001512.
Roy A, Roe MT, Neely ML, Cyr DD, Zamoryakhin D, Fox KA, White HD, Armstrong PW, Ohman EM, Prabhakaran D. Impact of Human Development Index on the profile and outcomes of patients with acute coronary syndrome. Heart. 2015 Feb;101(4):279-86. doi: 10.1136/heartjnl-2014-306389. Epub 2014 Dec 23.
Bakal JA, Roe MT, Ohman EM, Goodman SG, Fox KA, Zheng Y, Westerhout CM, Hochman JS, Lokhnygina Y, Brown EB, Armstrong PW. Applying novel methods to assess clinical outcomes: insights from the TRILOGY ACS trial. Eur Heart J. 2015 Feb 7;36(6):385-92a. doi: 10.1093/eurheartj/ehu262. Epub 2014 Jul 10.
Cornel JH, Ohman EM, Neely B, Clemmensen P, Sritara P, Zamoryakhin D, Armstrong PW, Prabhakaran D, White HD, Fox KA, Gurbel PA, Roe MT; TRILOGY ACS Investigators. Impact of smoking status on platelet function and clinical outcomes with prasugrel vs. clopidogrel in patients with acute coronary syndromes managed without revascularization: Insights from the TRILOGY ACS trial. Am Heart J. 2014 Jul;168(1):76-87.e1. doi: 10.1016/j.ahj.2014.04.011. Epub 2014 Apr 24. Erratum In: Am Heart J. 2014 Oct;168(4):605.
Wiviott SD, White HD, Ohman EM, Fox KA, Armstrong PW, Prabhakaran D, Hafley G, Lokhnygina Y, Boden WE, Hamm C, Clemmensen P, Nicolau JC, Menozzi A, Ruzyllo W, Widimsky P, Oto A, Leiva-Pons J, Pavlides G, Winters KJ, Roe MT, Bhatt DL. Prasugrel versus clopidogrel for patients with unstable angina or non-ST-segment elevation myocardial infarction with or without angiography: a secondary, prespecified analysis of the TRILOGY ACS trial. Lancet. 2013 Aug 17;382(9892):605-13. doi: 10.1016/S0140-6736(13)61451-8. Erratum In: Lancet. 2013 Aug 31;382(9894):768.
Gurbel PA, Erlinge D, Ohman EM, Neely B, Neely M, Goodman SG, Huber K, Chan MY, Cornel JH, Brown E, Zhou C, Jakubowski JA, White HD, Fox KA, Prabhakaran D, Armstrong PW, Tantry US, Roe MT; TRILOGY ACS Platelet Function Substudy Investigators. Platelet function during extended prasugrel and clopidogrel therapy for patients with ACS treated without revascularization: the TRILOGY ACS platelet function substudy. JAMA. 2012 Nov 7;308(17):1785-94. doi: 10.1001/jama.2012.17312.
Roe MT, Armstrong PW, Fox KA, White HD, Prabhakaran D, Goodman SG, Cornel JH, Bhatt DL, Clemmensen P, Martinez F, Ardissino D, Nicolau JC, Boden WE, Gurbel PA, Ruzyllo W, Dalby AJ, McGuire DK, Leiva-Pons JL, Parkhomenko A, Gottlieb S, Topacio GO, Hamm C, Pavlides G, Goudev AR, Oto A, Tseng CD, Merkely B, Gasparovic V, Corbalan R, Cinteza M, McLendon RC, Winters KJ, Brown EB, Lokhnygina Y, Aylward PE, Huber K, Hochman JS, Ohman EM; TRILOGY ACS Investigators. Prasugrel versus clopidogrel for acute coronary syndromes without revascularization. N Engl J Med. 2012 Oct 4;367(14):1297-309. doi: 10.1056/NEJMoa1205512. Epub 2012 Aug 25.
Jeong YH, Tantry US, Gurbel PA. Importance of potent P2Y(12) receptor blockade in acute myocardial infarction: focus on prasugrel. Expert Opin Pharmacother. 2012 Aug;13(12):1771-96. doi: 10.1517/14656566.2012.704909. Epub 2012 Jul 12.
Chin CT, Roe MT, Fox KA, Prabhakaran D, Marshall DA, Petitjean H, Lokhnygina Y, Brown E, Armstrong PW, White HD, Ohman EM; TRILOGY ACS Steering Committee. Study design and rationale of a comparison of prasugrel and clopidogrel in medically managed patients with unstable angina/non-ST-segment elevation myocardial infarction: the TaRgeted platelet Inhibition to cLarify the Optimal strateGy to medicallY manage Acute Coronary Syndromes (TRILOGY ACS) trial. Am Heart J. 2010 Jul;160(1):16-22.e1. doi: 10.1016/j.ahj.2010.04.022.
Public notes

Contacts
Principal investigator
Name 0 0
Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UC/GMT - 5 hours, EST)
Address 0 0
Eli Lilly and Company
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for public queries
Name 0 0
Address 0 0
Country 0 0
Phone 0 0
Fax 0 0
Email 0 0
Contact person for scientific queries



Summary Results

For IPD and results data, please see https://clinicaltrials.gov/study/NCT00699998